Sri International

The United States Government As Represented by the Department of Veterans Affairs

Wayne State University

Sanford-burnham Medical Research Institute

Oregon State University

La Jolla Cancer Research Foundation

Burnham Institute for Medical Research

Human Biomolecular Research Institute

Molecular Medicine Research Institute

Marcia L Dawson

Ling Jong

Peter D Hobbs

Joseph A Fontana

Magnus Pfahl

John R Cashman

Mark Mercola

Xiao-kun Zhang

Mark Leid

Jurgen M Lehmann

Zebin Xia

Paul J Bushway

Xiao-Kun Zhang

The invention provides compounds of formula I or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for inducing apoptosis or treating cancer using compounds of formula I. 

Therapeutic compounds

Methods and small molecule compounds for stem cell differentiation are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate, solvate or N-oxide thereof: Ris independently hydrogen or (C-C)alkyl; Ris independently hydrogen, (C-C)alkyl, aryl, or heteroaryl; Ris independently hydrogen, (C-C)alkyl, CFor CF; Ris independently (C-C)alkyl, aryl, 2-tetrahydrofurylmethyl, an aliphatic tertiary amine, or 4-methoxybenzyl; or Rand Rmay be joined together to form a 5 or 6 member ring lactone; Ris independently hydrogen, (C-C)alkyl, a 2- or 4-R-substituted aromatic ring selected from a 4-R-phenyl or a 2-R-5-pyridyl, aryl, heteroaryl, aliphatic tertiary amine or halogen; and R, R, R, R, R, R, are each independently hydrogen, (C-C)alkyl, aryl, optionally substituted phenyl, heteroaryl, a heterocyclic ring, an aliphatic tertiary amine, or halogen.

Benzimidazole compounds differentiate a mammalian stem cell into mesodermal or cardiomyocyte cells

The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

Induction of apoptosis in cancer cells

Bridged bicyclic aromatic compounds are provided having the structure ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n are as defined herein. The novel compounds are useful for modulating gene expression of retinoic acid receptors, vitamin D receptors and thyroid receptors. Pharmaceutical compositions and methods for modulating gene expression are provided as well.

Bridged bicyclic aromatic compounds and their use in modulating gene

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Menlo Park, CA, United States of America

Marcia L Dawson