Novartis Ag

Marcia Kay Ash

John Christopher Phelan

Courtney Flem Morgan

Yongxing Qiu

Lynn Cook Winterton

Rafael Victor Andino

John Martin Lally

Joseph Michael Lindacher

Angelika Maria Domschke

Michael Hugh Quinn

Allen Douglas Gilliard

Fiona Patricia Carney

Cornelius Daniel Niculas

Carol Ann Morris

Manal M Gabriel

Corneliu Daniel Niculas

Tomasz Jankiewicz

The present invention provides methods for lathing at room temperature a silicone hydrogel material, in particular silicone hydrogel material having a high oxygen permeability and made of a polymerizable composition containing a relative large amount of oxyperm component, into contact lenses.

Method for lathing silicone hydrogel lenses

The present invention provides silicone hydrogel materials having relatively high oxygen permeability and a relatively low modulus. The relatively-low modulus is achieved by adding a chain transfer agent into a polymerizable fluid composition in an amount sufficient to provide to the resultant silicone hydrogel material with a reduced modulus. In addition, the invention provides silicone hydrogel contact lenses comprising a silicone hydrogel material of the invention, a method for making a silicone hydrogel material of the invention, and a method for making a silicone hydrogel contact lens of the invention.

Silicone hydrogels

The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon.

Medical devices having antimicrobial coatings thereon

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Snellville, GA, United States of America

Marcia Kay Ash