Smithkline Beckman Corporation

Smithkline Corporation

Marcia C Shearer

Joseph R Valenta

Betty A Bowie

David J Newman

Kenneth M Snader

Robert D Sitrin

David J Cooper

Claude H Nash, Iii

Thomas O Lindsey

Richard D Hedde

Gail F Wasserman

Louis J Nisbet

Rajanikant Mehta

John J Dingerdissen

A novel antibiotic complex of 'vancomycin-like' antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.

Antibiotics produced by Kibdelosporangium aridum Shearer gen. nov., sp.

A novel subspecies of Kibdelosporangium aridum, subsp. largum (SK&F-AAD-609) produces AAD-216 antibiotics and AAD-609 antibiotics, the ADD-609 antibiotics differing from the AAD-216 antibiotics in presence of glucosamine in the glycolipid radical in place of amino glucuronic acid.

Kibdelosporangium aridum SK&F-AAD-609

Pure cultures of Kibdelsporangium aridum Shearer gen. nov., sp. nov.

A novel antibiotic complex of 'Vancomycin-like' antibiotics, AAD 216 complex, is produced by the cultivation of a fermentation broth containing Kibdelosporangium aridum Shearer gen. nov., sp. nov. ATCC 39323 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The AAD 216 complex and its major bioactive components; AAD 216A, AAD 216B, and AAD 216C exhibit antibiotic activity and growth promotant activity.

Antibiotics produced by Kibdelosporangium aridum shearer

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragile Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by streptosporangium fragile

A novel anthracycline antibiotic complex, fragilomycin complex, is produced by the cultivation of a fermentation broth containing Streptosporangium fragilis Shearer sp. nov. ATCC 31519 microorganisms in an aqueous nutrient medium under submerged aerobic conditions. The fragilomycin complex and its major bioactive component, fragilomycin A, exhibit antibiotic activity.

Anthracycline antibiotics produced by Streptosporangium fragilis Shearer

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Conshohocken, PA, United States of America

Marcia C Shearer