The United States of America, As Represented by the Secretary, Department of Health and Human Services

Marcelo J A Amar

Alan Thomas Remaley

H Bryan Brewer

Stephen J Demosky

Edward B Neufeld

John A Stonik

Fairwell Thomas

Disclosed herein are peptides and peptide analogs with multiple amphipathic &#x3b1;-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway, as well as peptides that activate lipoprotein lipase, and compositions comprising such peptides or combinations thereof. Also provided herein are methods of using multi-domain amphipathic &#x3b1;-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells and activate lipoprotein lipase within cells are also disclosed herein.

Peptides promoting lipid efflux

Disclosed herein are peptides or peptide analogs with multiple amphipathic &#x3b1;-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic &#x3b1;-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.

Multi-domain amphipathic helical peptides and methods of their use

Method of treating or inhibiting inflammation by multi-domain amphipathic helical peptides

Growing community of inventors

Gaithersburg, MD, United States of America

Marcelo J A Amar