The University of New Mexico

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Marcelo Amar

Bryce Chackerian

Alan Thomas Remaley

John T Schiller

Alexandra Fowler

John T Schillerr

A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.

Compositions comprising a PCSK9 peptide conjugated to a qbeta carrier and methods of using the same

An immunogen generally includes a virus-like particle and an antigen linked to the virus-like particle. The antigen includes an antigenic portion of a polypeptide, wherein the polypeptide inhibits lipoprotein lipase (LPL) activity by binding to LPL. In some embodiments, the polypeptide is at least a portion of angiopoietin-like 3 (ANGPTL3). In other embodiments, the polypeptide is at least a portion of angiopoietin-like 4 (ANGPTL4). In other embodiments, the polypeptide at least a portion of angiopoietin-like 8 (ANGPTL8). In some embodiments, the virus-like particle is a Qbeta immunogenic carrier. In some of these embodiments, the antigen is linked to the virus-like particle through a Gly-Gly-Gly-Cys linker at the C-terminal of the antigen.

Compositions and methods for reducing serum triglycerides

Composition comprising PCSK9 peptide conjugated to a Qbeta carrier and methods of using the same

PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same

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Gaithersburg, MD, United States of America

Marcelo Amar