Chemo Iberica, S.a.

Dipharma Francis S.r.l.

Dipharma S.p.a.

Quimica Sintetica, S.a.

Chemo Research, S.l.

Marcello Rasparini

Pietro Allegrini

Gabriele Razzetti

Giuseppe Barreca

Luca Carcone

Maurizio Taddei

Alberto Bologna

Elena Cini

Vittorio Lucchini

Roberto Rocco Tufaro

Graziano Castaldi

Antonio Zanotti-Gerosa

Simone Mantegazza

Domenico Magrone

Stephen James Roseblade

Giovanni Marras

Roberto Rossi

Fabio Morana

Luca Banfi

Gianpiero Ventimigla

Romina Vitale

Cosima Minelli

Huang Liming

Renata Riva

Adele Russo

Andrea Poggiali

Huan Liming

Francesca Musumeci

Fabio De Moliner

The invention relates to an industrially viable and advantageous process for the preparation of (2S,3 R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid, having the following formula (I) generally known as Droxidopa, or of intermediates useful in the synthesis thereof. 

Processes for the preparation of diastereomerically and enantiomerically enriched oxazolines

Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C. 

Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof

The invention relates to a process for the synthesis of Cariprazine, an antipsychotic compound useful in the treatment of positive and negative symptoms associated to schizophrenia, with the following structural formula: (A) The invention further relates to the synthesis of intermediates useful in the preparation of Cariprazine. 

1,4-cyclohexylamine derivatives and processes for the preparation thereof

A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described. 

Process for producing Aliskiren

It is described a process for the opening of lactone or lactam rings useful in the synthesis of pharmaceutically active compounds and the intermediates thereof, particularly Aliskiren. It has found that by selecting a type of solvent it is possible to obtain excellent yields and high optical and chemical purity of the isolated products.

Chemical process for opening ring compounds

A novel process is described for the synthesis of Sitagliptin, IUPAC name 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1 2,4-triazolo[4,3-a]pyrazine, of formula (I). 

Process for the production of sitagliptin

A process for the preparation of a compound of formula (I), or a salt thereof,  

Process for the preparation of pyridine-methylsulfinyl compounds

A process for the preparation of telmisartan (I) and novel intermediates useful for its synthesis. 

Process for the preparation of telmisartan

A process for preparation of a compound of formula (I), both as the isomeric mixture and individual isomers,  

Process for the preparation of pyridine compounds

A process for the preparation of phenyltetrazole derivatives of formula (II) wherein R and Y are as defined in the disclosure, by direct ortho-metallation of (tetrazol-5-&#x3b3;l)benzene. The compounds of formula (II) are useful intermediates for the preparation of angiotensin II antagonists. 

Process for the preparation of phenyltetrazole derivatives

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Pavia, Italy

Marcello Rasparini