University of Miami

Marcello Mascini

Sylvia Daunert

Sapna K Deo

Emre Dikici

Devon Pawley

Provided herein are methods implemented by a processor in a computer for designing a clamp peptide comprising the structure A-B-Awherein Ais a first peptide arm that binds to a first binding site of a target protein, Ais a second peptide arm that binds to a second binding site of the target protein, and B is a bridge peptide which links Ato A. Also provided herein are computer-readable storage media having stored thereon machine-readable instructions executable by a processor and systems. Related methods of manufacturing a clamp peptide and the clamp peptides manufactures by the methods are provided.

Methods of designing novel antibody mimetics for use in detecting antigens and as therapeutic agents

Provided herein are Zika virus (ZIKV) binding constructs, e.g., antibodies and antigen-binding fragments thereof and antibody mimetics, as well as related conjugates, polypeptides, nucleic acids, expression vectors, host cells, kits, and assay systems. Methods detecting ZIKV infection and/or ZIKV exposure and/or ZIKV immunity are provided.

Growing community of inventors

Teramo, Italy

Marcello Mascini