Aduro Biotech Inc.

Johns Hopkins University

Marcella Fasso

Dirk G Brockstedt

Peter M Lauer

Meredith Lai Ling Leong

William G Hanson

Thomas W Dubensky, Jr

Justin Skoble

Charles George Drake

Christopher Steven Rae

Dirk Brockstedt

Thomas Dubensky

Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.

Immunogenic fusion proteins for the treatment of cancer

The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues.

Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

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Richmond, CA, United States of America

Marcella Fasso