Allergan, Inc.

Marcella A Gilmore

Kei Roger Aoki

Lance Steward

Ester Fernandez-Salas

Joseph Francis

Shengwen Li

Sanjiv Ghanshani

Dudley J Williams

Marc F Verhagen

J Oliver Dolly

Fernandez-Salas Ester

Ronald G Miller

Shengwin Li

Joseph A Francis

Lance E Steward

Kei Roger Acki

Ester E Fernandez-Salas

Iance E Steward

The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

Degradable clostridial toxins

Degradable Clostridial toxins

The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.

Modified Clostridial toxins with enhanced targeting capabilities for endogenous Clostridial toxin receptor systems

The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an enhanced targeting domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.

Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity

Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells

Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.

Activatable clostridial toxins

Growing community of inventors

Santa Ana, CA, United States of America

Marcella A Gilmore