Johns Hopkins University

Institute of Organic Chemistry and Biochemistry Ascr, V.v.i.

K.u. Leuven Research & Development

Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic

Inst of Organic Chem. and Biochemistry As Cr V.v.i

Marcela Krecmerova

Barbara S Slusher

Rana Rais

Pavel Majer

Andrej Jancarik

Tomas Tichy

Johan Neyts

Erik De Clercq

Lukas Tenora

Luis Garza

Ivan Snajdr

Mohameed Islam

Antonin Holy

Benjamin Bell

Alois Piskala

Graciela Andrei

Robert Snoeck

Lieve Naesens

Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.

Prodrugs of itaconate and methyl itaconate

Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.

Prodrugs of prostate specific membrane antigen (PSMA) inhibitor

The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising such 5-azacytosine derivatives as active ingredients in combination with pharmaceutically acceptable carriers, which are useful for the treatment of subjects suffering from viral infections.

Azacytosine derivatives useful as antiviral agents

Growing community of inventors

Prague, Czechia

Marcela Krecmerova