Hoffmann-la Roche Inc.

Other

Schering Aktiengesellschaft

Marcel Muller

Leo Alig

Andor Furst

Rudolf Wiechert

Ulrich Kerb

Thomas Weller

Peter Keller

Georges Hirth

Volker Breu

Werner Neidhart

Albrecht Edenhofer

Arnold Trzeciak

Henri Ramuz

Martine Clozel

Beat Steiner

Paul Hadvary

Jean-Marie Cassal

Kaspar Burri

Bernd-Michael Loffler

Klaus Kieslich

Marianne Hurzeler

Eric Vieira

Wolfgang Wostl

Jurg Albert Gutzwiller

Heinz Stadler

Alfred Binggeli

Daniel Bur

Walter Fischli

Robert C Nickolson

Maurice Wilhelm

Christian Oefner

Hans-Peter Marki

Marianne Hurzeler Muller

Rolf Guller

Gunter Neef

Ulrich Eder

Karl Petzoldt

Werner Bollag

Quirico Branca

Paul Zeller

Ado Kaiser

Marie-Paule Heitz

Balthasar Hegedus

Hugo Gutmann

Albert Langemann

Stadler Heinz

Piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.

Piperidine derivative having renin inhibiting activity

Compounds of formula I ##STR1## wherein R.sup.1 signifies phenyl, substituted phenyl or heterocyclyl;

Aryl-  and hetaryl-sulfonamide derivatives, their preparation and their

Novel piperidine derivatives, their manufacture and use as medicaments, are disclosed. The invention is concerned with the novel piperidine derivatives of general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Z, m and n are as described herein.

Piperidine derivatives having renin inhibiting activity

Sulfonamides

Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell--cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitrites.

Acetic acid derivatives

Aryl- and hetaryl-sulfonamide derivatives, their preparation and their

Compounds of formula I: ##STR1## are disclosed. The compounds inhibit the binding of endothelin to its receptors.

Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin

Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.

Sulphonamides

N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'' and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion. They are manufactured by cleaving off protecting groups in corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.

Amino acid derivatives

Acetic acid derivatives of the formula ##STR1## wherein L, M, T and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion, and are manufactured by cleaving protecting groups in the corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.

N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'' and Q have the definitions given in the specification, are for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets, by blood platelet aggregation and cell-cell adhesion. They are manufactured by cleaving off protecting groups in corresponding protected compounds or by converting the cyano group into the amidino group in corresponding nitriles.

Disclosed herein are peptide of the formula

Antithrombic peptides

N-Acyl-.alpha.-aminocarboxylic acid derivatives of the formula ##STR1## wherein L, R' to R'' and Q have the significance given in the description, can be used for the treatment or prophylaxis of illnesses which are caused by the binding of adhesive proteins to blood platelets and by blood platelet aggregation and cell-cell adhesion.

Peptides bearing N-terminal amidino moieties and their use as inhibitors

The invention is concerned with novel sulphonamides and their use as medicaments. In particular, the invention is concerned with compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, halogen or trifluoromethyl;

Phenylsulfonylamide pyrimidine

Growing community of inventors

Frenkendorf, Switzerland

Marcel Muller