Crucell Holland B.v.

Applied Nanosystems B.v.

Marcel Leo De Vocht

Marloes Veenstra

Herman Abel B Wösten

Joseph Gerard H Wessels

The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA fragmentation and/or precipitation followed by a clarification step with tangential flow filtration.

Process for adenovirus purification from high cell density cultures

The invention provides methods for large-scale adenovirus purification from high cell density suspensions, using host cell DNA precipitation followed by a clarification step.

Method for the purification of adenovirus particles

The invention relates to a method of purifying a hydrophobin present in a hydrophobin-containing solution. According to the invention the solution is contacted with a surface for the adsorption to that surface, and separated from a solution depleted in hydrophobin. Subsequently the surface is contacted with a solution containing a surfactant at a temperature lower than 90&#xb0; C. Desorbed hydrophobin is separated from said surface.

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Woerden, Netherlands

Marcel Leo De Vocht