Sandoz Gmbh

Marcel K Eberle

Robert E Manning

2-amino-5-(substituted or unsubstituted phenylalkyl)-1,3,4-thiadiazoles, e.g., 2-amino-5-(3-trifluoromethylbenzyl)-1,3,4-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thiosemicarbazide in a strong acid medium. The compounds are useful as minor tranquilizers and sleep inducers.

2-Amino-5-(trifluoromethylphenylalkyl)-1,3,4 thiadiazoles used in the

1-dioxolanylpropyl-3-indoleacrylic acid esters, e.g., 1-[3-(2-methyl-2-dioxolanyl)propyl]-3-indoleacrylic acid ethyl ester, are prepared by reacting a corresponding 1-dioxolanylpropyl-3-indolecarboxaldehyde with carbalkoxymethylene triphenylphosphorane and are useful as hypolipidemic agents.

1-Dioxolanylpropyl-3-indoleacrylic acid esters

2-amino-5-(substituted or unsubstituted phenylalkyl)-thiadiazoles, e.g., 2-amino-5-(4-[phenylbutyl])-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thiosemicarbazide in a strong acid medium. The compounds are useful as minor tranquilizers and sedative hypnotics.

2-Amino-5-(substituted or unsubstituted phenylalkyl)-thiadiazoles

2-amino-5-(substituted or unsubstituted phenylalkyl)-1,3,4-thiadiazoles, e.g., 2-amino-5-(3-trifluoromethylbenzyl)-1,3,4-thiadiazole, prepared, e.g., by ring closure, of corresponding 1-(substituted or unsubstituted phenylalkanoyl)-thio-semicarbazide in a strong acid medium. The compounds are useful as minor tranquilizers and sleep inducers.

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Madison, NJ, United States of America

Marcel K Eberle