Dsm IP Assets B.v.

Marcel Joray

René Tobias Stemmler

Werner Bonrath

Thomas Netscher

Jonathan Alan Medlock

Raphael Beumer

Manfred Breuninger

Domenico Soriano

Jan-Marc Delpho

The present invention relates to the manufacturing of a process of alkyl 2-acetyl-5,9,13-trimethyltetradeca-4,8,12-trienoates and alkyl 2-acetyl-9,13-di-methyl-5-methylenetetradeca-8,12-dienoate as well as 6,10,14-trimethylpenta-deca-5,9,13-trien-2-one and 10,14-dimethyl-6-methylenepentadeca-9,13-dien-2-5 one and 6,10,14-trimethylpentadecan-2-one.

Synthesis of alkyl 2-acetyl-5,9,13-trimethyltetradeca-4,8,12-trienoates and derivatives by a non-continuous production process

The present invention relates to novel compounds which are particularly useful for the synthesis of novel chromanol derivatives. These compounds have interesting properties. Particularly, the novel chromanol derivatives have interesting antioxidant properties as well as flavours and fragrances.

6-chromanol derivatives and their synthesis

Process for the preparation of hydroxytyrosol, characterized by reacting 4-chloroacetyl-catechol with a metal formate and formic acid in an aqueous solvent optionally containing a lower alkanol and catalytically hydrogenating the 4-hydroxyacetyl-catechol obtained in the presence of a precious metal, preferably on a carrier.

Process for the preparation of hydroxytyrosol

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Kaiseraugst, Switzerland

Marcel Joray