Pfizer Corporation

Icagen, Inc.

Marcel John De Groot

Alan Daniel Brown

David James Rawson

Nigel Alan Swain

Robert Ian Storer

Paul Anthony Stupple

Andrew Simon Bell

Russell Andrew Lewthwaite

David Simon Millan

Ian Roger Marsh

Manuel Perez Pacheco

Nunzio Sciammetta

Brian Edward Marron

Thomas Ryckmans

Christopher William West

Steven Matthieu Gaulier

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z, R, R, R, R, R, Rand Rare as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

Chemical compounds

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar, X, R, R, R, Rand Rare as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.

This invention relates to sulfonamide derivative of formula (I), to their use in medicine, to compositions containing them, to processes for their preparation, and to intermediates used in such processes.  These compounds are inhibitors of Nav1.7.

Sulfonamide derivatives as Nav 1.7 inhibitors

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Sandwich, United Kingdom

Marcel John De Groot