Merrell Dow Pharmaceuticals

Universitéde Strasbourg

Centre National De La Recherche Scientifique

Northwestern University

Merrell Pharmaceuticals, Inc.

Institut National De La Sante Et De La Recherche Medicale

Université Paris—sud

Centre International De Recherche Aux Frontieres De La Chimie

Centre National De La Recherche Scientifique, a Scientific Research Centre

Merrell Dow France Et Cie.

Marcel Hibert

Maurice W Gittos

Jean-Jacques Bourguignon

Jacques Haiech

Linda J Van Eldik

Anastasia Velentza

Magdalena Zasadzki

Wenhui Hu

D Martin Watterson

Daniel Martin Watterson

Thomas J Lukas

Anu R Sawkar

Salida Mirzoeva

Linda Van Eldik

Sylviane Muller

Dominique Bonnet

Jean-Luc Galzi

Luc Van Hijfte

Christophe Guignabert

Paul Moser

Nelly Frossard

Martin Watterson

Linda Van El Dik

Anastasia Veleniza

Magdaena Zasadzki

Mary Richards

Frédéric Simonin

Jean-Jacques Bouguignon

Magdelena Zasadzki

A subject of the present invention is a compound having the general formula (I):  Another subject of the invention is the compound as defined above for use as a medicament, in particular for preventing and/or treating inflammation and inflammatory diseases, immune and auto-immune diseases, pain related diseases, genetic diseases and/or cancer.

Pyrimidinone derivatives and uses thereof to neutralize the biological activity of chemokines

The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

Pyridazine compounds, compositions and methods

The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.

The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

A novel class of pyridazine compositions and related methods of use.

Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death

The invention relates to novel chemical compounds of Formula I compositions and methods of using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.

Pyridazine compounds and methods

This invention relates to the manufacture of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines and their use as medicaments in the treatment of cognitive disorders.

Use of certain esters of

This invention relates to novel derivatives of 5H-dibenzo (a,d)cycloheptenes, to the processes for their preparation, to their muscarinic receptor antagonist properties and to their end-use application for treating Parkinson's Disease, tardive dyskinesia, and motion sickness.

5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists

This invention relates to novel derivatives of 1,7'-[imidazo-[1,2-a]pyridine]5'-(6'H)ones, to the method for their preparation and to their use as anti-hypertensive, anxiety, anti-depressant and anti-migraine agents, and to their use as appetite regulators useful for the treatment of anorexia and obesity.

Certain pharmaceutically active 6H-imidazo[1,2-a]pyridine-5-ones

This invention relates to aromatic 2-aminoalkyl derivatives of 1,2-benzoisothiazol-3(2H)one-1,1-dioxides, processes for the preparation of same, and to their use as anxiolytic and antihypertensive agents.

Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide

Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)-one-1,1-dioxide

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Eschau, France

Marcel Hibert