Laboratoire Roger Bellon

Laboratorie Roger Bellon

Dainippon Pharmaceutical

Laboratoire Roger Bellow

Marcel E Pesson

Henri Techer

Suzanne W Geiger

Francoise Roquet

Michel Joannic

Gilles Monnier

Novel compounds with .beta.-adrenergic properties comprising 1-[1-benzimidazolyl] N-[2-(4-hydroxy 3-methoxy phenyl) 2-hydroxy ethyl]3-amino butane, corresponding to the following formula ##STR1## as well as its addition salts with pharmaceutically acceptable non-toxic inorganic or organic acids, and the hydrates of said salts. These compounds are particularly useful for the treatment of asthma and in the case of premature labor.

.beta.-Adrenergic

1-Aryl-4-.gamma.-arylsulphonyl-3-aminopropoxy-1H-pyrazoles of the formula: ##STR1## and their acid addition salts. Application of these compounds as medicaments useful in particular as hypolipemiant or hypocholesterolemiant agents.

1-Aryl-4-.gamma.-arylsulphonyl-3-aminopropoxy-1H-pyrazoles and their use

New 7-dialkylamino-1-substituted-6-halogeno-4-oxo-1,4-dihydroquinoline-3 carboxylic acids of the formula: ##STR1## wherein the R.sub.1 substituent is methyl, ethyl, vinyl or allyl and non-toxic pharmaceutically acceptable acid addition salts thereof. These compounds are useful as antibacterial agents. Also disclosed are processes for preparing the compounds.

1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their

Valuable antibacterial 8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acids, some of which are new compounds, are made from corresponding pyrimidines by a process involving condensation with an amino-ester, cyclization, halogenation, dehydrohalogenation, and saponification.

Process for the preparation of an

Process for the preparation of a 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine of the formula: ##STR1## IN WHICH R.sub.1 is a lower alkyl radical with 1 to 4 carbon atoms, which comprises the following stages: A) condensation of a salt of O-methylisourea and an inorganic or organic acid, with an alkyl alkoxymethylenemalonate ##STR2## in an aqueous medium and in the presence of an excess of an alkali metal hydroxide, to form the corresponding salt of the 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and neutralization of the said salt by the addition of an inorganic or organic acid, in order to liberate this 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and ##STR3## B) bringing the latter compound, suspended in dimethylformamide, into contact with thionyl chloride, at room temperature, in order to form the corresponding 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine: ##STR4##

Process for the preparation of

8-Alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acids for

This invention relates to 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydro-indoles, and acid addition salts thereof. In particular, the compounds have (.beta.-aminoethoxy- or .gamma.-amino-propoxy)-phenyl substituents, the amino groups in each case either being joined to two C.sub.1.sub.-5 alkyl groups or forming part of a heterocyclic group such as a pyrolidino, piperidino or morpholino group. Compounds in accordance with the invention have been found to exhibit interesting actions on the cardiovascular system in particular as vasodilators.

Growing community of inventors

Paris, France

Marcel E Pesson