Sanofi

Labaz

S.a. Labaz N.v.

Marcel Descamps

Dino Nisato

Jean Gubin

Henri Inion

Pierre P Chatelain

Jean Lucchetti

Jean-Noel Vallat

Jean-Marie Mahaux

Walter Verstraeten

Yves Berger

Charles Goldenberg

Gerard R Le Fur

Peter Polster

Claire Urbain, Legal Representative

Marcel Urbain, Deceased

Alex Areschka

Nadine C Urbain, Legal Representative

Georges Sayac

Jean P Urbain, Legal Representative

Jacques J Urbain, Legal Representative

The present invention relates to aminoalkoxyphenyl compounds of formula: ##STR1## in which: B is selected from --S--, --SO-- and --SO.sub.2 --,

Aminoalkoxyphenyl derivatives, process of preparation and compositions

Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group,

Pyrozala-pyridyl aminoabkoxyphenol compounds

Benzofuranyl aminoalkoxyphenyl compounds

The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case.

Use of aminoalkoxyphenyl derivatives for reducing and/or controlling

The invention relates to new 4-hydroxyindole derivatives of general formula: ##STR1## in which R represents a labile protective group and R.sub.1 can represent hydrogen, a C.sub.1 -C.sub.6 alkyl radical, a C.sub.3 -C.sub.6 cycloalkyl radical, a lower alkoxy radical, a lower hydroxyalkyl radical, a lower (lower alkoxy) alkyl radical, a phenyl radical optionally substituted with a halogen atom or a lower alkyl or lower alkoxy radical, a cyano radical, a radical of formula ##STR2## in which R.sub.2 and R.sub.3, which may be identical or different, each represent hydrogen or a lower alkyl radical, R.sub.4 represents a hydroxy group, a lower alkyl or lower alkoxy radical or a radical ##STR3## in which R.sub.2 and R.sub.3 have the same meaning as above, R.sub.5 represents a lower alkyl radical and Alk represents a single bond or a straight- or branched-chain alkylene radical having from 1 to 4 carbon atoms. The invention also relates to a process for preparing 4-(3-amino-2-hydroxypropoxy)indole derivatives from the said 4-hydroxyindole derivatives.

4-hydroxyindole derivatives, the process for preparation thereof and

The process for the preparation of the E isomers of the compounds of formula A: ##STR1## in which R.sub.1 is selected from H or C.sub.1 -C.sub.4 alkyl, comprises according to the invention the reaction of propionaldehyde with a phosphorus derivative of formula: ##STR2## in which R.sub.1 designates C.sub.1 -C.sub.4 alkyl and R.sub.2 is selected from C.sub.1 -C.sub.4 alkyl or phenyl, and, optionally, the hydrolysis of the compound of formula A in which R.sub.1 is alkyl in order to form the compounds of formula A in which R.sub.1 is H. Pharmaceutical industry.

Process for the preparation of 2-propyl-2-pentenoic acid and its esters

An aminoalkoxyphenyl compound of formula ##STR1## as well as a pharmaceutically acceptable salt of this compound.

The invention relates to 4-amino-butanoic acid derivatives of general formula: ##STR1## in which: M represents an alkali metal atom,

4-Amino-butanoic acid derivatives

The invention relates to new (4S)-4-aminobutanoic acid derivatives of general formula: ##STR1## in which: R represents an N-protective group,

4-aminobutanoic acid derivatives, process of preparation and use thereof

Pharmaceutical and veterinary compositions having as essential active ingredient at least one benzofuran derivative of the general formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof in which R represents an amino, monoethylamino or diethylamino radical and X.sub.1 and X.sub.2 represent hydrogen or iodine with the proviso that when R represents diethylamino X.sub.1 and X.sub.2 are different. These compositions are useful for the treatment of ischemic cardiac disorders.

Pharmaceutical and veterinary compositions for the treatment of ischemic

Benzofuran derivatives represented by the general formula: ##STR1## in which: R represents an ethyl, n-propyl, isopropyl or n-butyl radical;

Benzofuran derivatives and their therapeutic use

Novel pyridoxine derivatives represented by the general formula: ##STR1## in which: R represents a radical ##STR2## --CH.sub.2 --(CH.sub.2).sub.n --CH.sub.2 --OR.sub.2 or ##STR3## in which n represents 0 or 1, X and X.sub.1, which are different, represent hydrogen or methyl, Y represents hydrogen or methyl and R.sub.2 represents a phenyl group non-substituted or bearing one or two substituents selected from the group consisting of fluorine, chlorine and bromine and of the radicals methyl, ethyl, n-propyl, isopropyl and methoxy,

Pyridoxine derivatives, and use in therapeutics

The invention relates to novel aniline derivatives of the formula: ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen or chlorine atom, an allyloxy, acetamide or carboxamide group, R.sub.3 represents a methyl or an optionally substituted phenyl group, R.sub.4 represents a hydrogen atom and R.sub.5 an isopropyl, terbutyl, 2-phenoxy-ethyl or 3-phenyl-propyl group or R.sub.3 and R.sub.5 taken together form with the nitrogen atom a substituted heterocyclic group. The compounds of the invention are useful for the treatment of angina pectoris.

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Wavre, Belgium

Marcel Descamps