Technische Universiteit Eindhoven

Stichting Voor De Technische Wetenschappen

Marcel Cornelis Maria Rutten

Franciscus Petrus Thomas Baaijens

Jeroen Kortsmit

Niels Jozef Bart Driessen

Method for manufacturing a tissue-engineered construct, such as a heart valve, comprising the steps of providing a-cell-seeded scaffold in a bioreactor chamber which bioreactor chamber is divided by the cell-seeded scaffold into a first compartment and a second compartment, subjecting the cell-seeded scaffold to a flow of nutrient medium within the bioreactor chamber for developing the cell-seeded scaffold to a tissue structure and next to the tissue construct, applying a dynamic pressure difference to the developing tissue structure by the flow of nutrient medium to induce dynamic strain on the tissue structure.

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Eindhoven, Netherlands

Marcel Cornelis Maria Rutten