Janssen Pharmaceutica Nv

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Janssen Pharmaceutica

Marcel August Constant Janssen

Jan Heeres

Donald William Ludovici

Paul Adriaan Jan Janssen

Koenraad Jozef Lodewijk Marcel Andries

Lucien Maria Henricus Koymans

Chih Yung Ho

Michael Joseph Kukla

Koen Jeanne Alfons Van Aken

Bart L De Corte

Marc Ren&eacute; De Jonge

Marc René De Jonge

This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CRor N; n is 0 to 4; Q is hydrogen or &#x2014;NRR; Rand Rare selected from hydrogen, hydroxy, Calkyl, Calkyloxy, Calkylcarbonyl, Calkyloxycarbonyl, aryl, amino, mono- or di(Calkyl)-amino, mono- or di(Calkyl)aminocarbonyl wherein each Calkyl may optionally be substituted; or Rand Rtaken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(Calkyl)aminoCalkylidene; Ris hydrogen, aryl, Calkylcarbonyl, optionally substituted Calkyl, Calkyloxy-carbonyl; and Ris hydroxy, halo, optionally substituted Calkyl, Calkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; Ris hydrogen or Calkyl; L is optionally substituted Calkyl, Calkenyl, Calkynyl, Ccycloalkyl; or L is &#x2014;X&#x2014;Ror &#x2014;X-Alk-Rwherein Rand Rare optionally substituted phenyl; Xand Xare &#x2014;NR&#x2014;, &#x2014;NH&#x2014;NH&#x2014;, &#x2014;N&#x2550;N&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;S(&#x2550;O)&#x2014; or &#x2014;S(&#x2550;O)&#x2014;; Alk is Calkanediyl; aryl is optionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

HIV inhibiting pyrimidine derivatives

This invention concerns the use of the compounds of formula

HIV Inhibiting pyrimidine derivatives

HIV inhibiting pyrimidine derivative

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Vosselaar, Belgium

Marcel August Constant Janssen