Evonik Operations Gmbh

Marcel Arndt

Jürgen Erwin Lang

Mario Gomez

Shraddha Joshi

Ashish Guha

Vinay Jain

Hans Bär

Felix Hofmann

Miriam Robota

Vishal Kaneria

Present invention relates to an apparatus () for producing nanocarriers and/or nanoformulation and a process for producing a nanocarrier and/or a nanoformulation by means of this apparatus (). According to inventive preparation, a first liquid phase (A) and the second liquid phase (B) are mixed first to give the primary mixture (A+B) by means of a static mixer (). In a subsequence mixing step primary mixture (A+B) is diluted with a third liquid (C). An important aspect of apparatus () is the arrangement of the static mixer () inside a linear pipe () conducting third liquid phase (C). Thus, the primary mixture (A+B) exiting the mixer () is instantaneously diluted with (C) to give secondary mixture (A+B+C). The volume flow of the third mixture (C) is chosen larger than the volume flow of the primary mixture (A+B). By these measures, nanocarriers with improved morphology and homogeneity are produced. Encapsulation efficiency was enhanced as well.

Nanocarrier manufacturing

A process prepares a polymer-coated hard shell capsule, suitable as container for pharmaceutical or nutraceutical biologically active ingredients. The hard shell capsule can include a body and a cap. In the closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The hard shell capsule can be provided in the pre-locked state and spray-coated with a coating solution, suspension, or dispersion that includes a polymer or a mixture of polymers to create a coating layer which covers the outer surface of the hard shell capsule in the pre-locked state.

Process for preparing a coated hard shell capsule

An apparatus and corresponding process can be used for producing nanocarriers and or nanoformulations and corresponding process products. The apparatus is characterized by a vertical orientation of the feed conduits leading to active element. The feed conduits are nested within one another and are axially movable in terms of their orientation to one another. The process provides for the mixing of at least two liquid phases with different acidities. The volume flow of the first phase is greater than that of the second phase.

Apparatus and process for producing nanocarriers and/or nanoformulations

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Moerfelden-Walldorf, Germany

Marcel Arndt