Aventis Pharma S.a.

Sanofi

Sanofi-aventis

Marcel Alasia

Patrick Mailliet

Jean-Marie Ruxer

Gilles Doerflinger

Thomas Caulfield

Abdelazize Laoui

Jean-Louis Mergny

Odile Petitgenet

Emmanuelle Renou

Frank Halley

Maria Mendez-Perez

Victor Certal

Hervé Minoux

Luc Bertin

Jean-Francois Riou

Jean-François Riou

The invention relates to the novel substances in Formula (I): wherein Het is a heterocycle optionally substituted by one or a plurality of radicals R1 or R'1; R is selected from the group comprising Formula (A&#x2032;), (B), (C), (D), or (E), with R1 and/or R&#x2032;1 selected from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalcoxy, alkylhio, or carboxy that is free or esterified by an alkyl, carboxamide, CO&#x2014;NH(alkyl), CON(alkyl)2, NH&#x2014;CO-alkyl, sulfonamide, NH&#x2014;S02-alkyl, S(0)2-NHalkyl, or S(02)-N(alkyl)2 radical; all these radicals are optionally substituted; W1, W2, and W3 independently are CH or N; X is 0, S, NR2, C(O), S(O), or S(0)2; Z is optionally substituted H, Hal, -0-R2 or &#x2014;NH&#x2014;R2 with R2 being H, alkyl, cycloalkyl, or heterocycloalkyl; and these substances are all isomeric forms and salts thereof, used as drugs. 

HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof

Pyrroloindoles of formula (I) are provided wherein Het is an aromatic or partially unsaturated, monocyclic or bicyclic heterocycle containing between 1 and 4 heteroatoms N, O or S, optionally substituted by R1 or R'1 which are the same or different; R is X-(A-B)n-CONH2, X-(A-B)n-O&#x2014;CONH2, X-(A-B)n-NH&#x2014;CONH2, X&#x2014;(CH2)m-heterocycloalkyl, X(CH2)m-aryl and X&#x2014;(CH2)m-heteroaryl wherein X is &#x2014;O&#x2014;C(O), &#x2014;NH&#x2014;C(O), NH&#x2014;CS, &#x2014;NH&#x2014;CO&#x2014;CH2-O&#x2014;; &#x2014;NH&#x2014;COCH2-S&#x2014;CH2-CO&#x2014;NH&#x2014;; &#x2014;NH&#x2014;CO&#x2014;(CH2)2-SO2-; and &#x2014;NH&#x2014;CO&#x2014;CH2-N(CH3)-CO&#x2014;; A and B are the same or different and are each independently a single bond, CH2, CH-alkyl, and CH-aralkyl; n=1, 2 and m=0, 1; R1 and/or R&#x2032;1 are H, halogen, CF3, nitro, cyano, alkyle, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, and carboxy, free or esterified by an alkyl, carboxamide, CONH(alkyl), CON(alkyl)2, NH&#x2014;CO-alkyl, sulfonamide, NH&#x2014;SO2-alkyl, S(O)2-NHalkyl, and S(O2)-N(alkyl)2 group, all of said alkyl, alcoxy and alkylthio groups being optionally substituted themselves, said products being in all isomer forms and salts, as medicaments.

Derivatives of pyrroloindole which are inhibitors of Hsp90, compositions containing same, and use thereof

The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans.

Chemical derivatives and their application as antitelomerase agents

Growing community of inventors

Paris, France

Marcel Alasia