Amgen Inc.

Marc W Retter

Randal Robert Ketchem

Jeonghoon Sun

Mark Leo Michaels

Mei-Mei Tsai

Susie Miki Harris

Seog Joon Han

Ji Lu

Susie M Harris

Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fragment, that is, little or no binding activity at a physiologic pH. Also described are variant Fc-polypeptides that comprise these variant Fc-fragments. Further described are methods of making and identifying such Fc-fragments and methods for making and using such Fc-polypeptides.

Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor

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Simi Valley, CA, United States of America

Marc W Retter