Centre National De La Recherche Scientifique

Universitè De Montpellier

Universite Paris Cité

Metafora Biosystems

Leland Stanford Junior University

Université Montpellier 2 Sciences Et Techniques

Inserm (Institut National De La Sante Et De La Recherche Medicale)

Universite Montpellier 2

Université Montpellier Ii

Marc Sitbon

Bruno Robert

Jean-Luc Battini

Naomi Taylor

Felix Jinhyun Kim

Sandrina Kinet

Vincent Petit

Nicolas Gabriel Albert Manel

Valérie Courgnaud

Jawida Lezaar

Jean-Luc Georges Laurent Battini

Donatella Giovannini

Nicolas Manel

Rabindra M Tirouvanziam

Cedric Mongellaz

Julien Bellis

Svilena Ivanova

Julie Laval

Guangqi E

Jawida Touhami

Muriel Busson

Samuel Sevestre

Methods for detecting and/or measuring the level of sodium-dependent multivitamin transporter (SMVT) in a biological sample. The methods include the steps of: (a) contacting the biological sample with a PERV-B.RBD ligand, a variant and/or a fragment thereof; and, detecting and/or measuring the binding of the PERV-B.RBD ligand, variant and/or fragment thereof to SMVT.

Use of ligands derived from receptor-binding domain of porcine endogenous retrovirus type B for diagnosing SMVT-related diseases

Disclosed are methods for diagnosing CAT1-related diseases, wherein the methods include detecting CAT1 in a cell by a BLV.RBD ligand, or a variant or a fragment thereof. Also disclosed is a BLV.RBD ligand, or a variant or a fragment thereof for use in the treatment of CAT1-related diseases and/or BLV infections.

Use of receptor-binding domain derived from bovine leukemia virus for the diagnosis or treatment of cationic l-amino acid transporter-related diseases

A method for the identification and quantification of the expression of membrane receptors present on the surface of target cells using at least two soluble receptor binding ligands derived from the soluble part of the glycoprotein of an enveloped virus that interacts with a cellular cognate receptor, the receptor binding ligand containing a part or the totality of one of the receptor binding domains (RBD) of the glycoprotein, and the soluble receptor binding ligand being liable to interact with the at least one membrane receptor of a target cell, for the identification and quantification of the expression of membrane receptors present on the surface of target cells, the identification and quantification taking place at a given time or during a given time interval, and allowing the determination of a physiological state of the target cell.

Receptor binding ligands, their use in the detection of cells with biological interest

The present application relates to polypeptides derived from the soluble part of the glycoprotein of the enveloped virus of Primate T-cell leukemia virus (PTLV), or fragments or variants thereof named receptor binding domain ligands (RBD) selected for their ability to bind specifically to the nutrient transporter GLUT1.

GLUT-1 as a receptor for HTLV envelopes and its uses

A method for the diagnosis and/or prognosis of inflammatory states, and the use of at least one soluble receptor-binding (RBD), for the identification and quantification of the expression of membrane receptors present on the surface of target granulocytes, said identification and quantification taking place at a given time or during a given time interval, and allowing the diagnosis and/or prognosis of inflammatory states in a mammal.

Method for the diagnosis and/or prognosis of granulocyte-related inflammatory states

The invention relates to the use of the ubiquitous vertebrate glucose transporter GLUT1, or of fragments or sequences derived thereof, for the in vitro diagnosis of cancers, when used as a tumor marker, or for the screening of compounds useful for the preparation of drugs for the prevention or the treatment of pathologies linked to an infection of an individual with a PTLV, or pathologies linked to an overexpression of GLUT1 on cell surfaces, or the in vitro detection of GLUT1 on cell surfaces. The invention also relates to pharmaceutical compositions containing GLUT1, or fragments or sequences derived thereof, and to their uses such as in the frame of the prevention or the treatment of pathologies linked to an infection of an individual with a PTLV.

Glut-1 as a receptor for HTLV envelopes and its uses

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Montpellier, France

Marc Sitbon