Inhale Therapeutic Systems, Inc.

Nektar Therapeutics

Novartis Pharma Ag

Marc S Gordon

Andrew Clark

Thomas K Brewer

Shirley W Lyons

Keith A Johnson

Sandeep Kumar

Bing Yang

John D Lord

Michael Weikert

Razaq Sarwar

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.

Systems and processes for spray drying hydrophobic and hydrophilic components

The present invention provides spray-dried polyene compositions for oral inhalation to the lung. The polyene antifungal compositions demonstrate superior aerosol properties, do not exhibit appreciable degradation of the polyene upon spray-drying, and are useful in the treatment and prophylaxis of both pulmonary and systemic fungal infections.

Pulmonary delivery of polyene antifungal agents

Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients

The invention provides an agglomerate composition composed of units of aggregated fine particles and methods for its manufacture and use. The agglomerate composition units are composed of fine particles having a mean particle size in the range of 1 .mu.m to 5 .mu.m, and usually includes a medicament powder. The agglomerate units have a mean size in the range from 200 .mu.m to 500 .mu.m and have a friability index in the range from about 10 to 60.

Methods and system for processing dispersible fine powders

Systems and processes for spray drying hydrophobic drugs with

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. The hydrophilic component is dissolved in an aqueous solution and the hydrophobic component suspended therein. The method provides dry powders having relatively uniform characteristics.

Processes for spray drying aqueous suspensions of hydrophobic drugs and

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. Both the hydrophobic and hydrophilic component are dissolved in a solvent system selected to have adequate solubility for both components. The method provides dry powders having relatively uniform characteristics.

Processes for spray drying solutions of hydrophobic drugs and

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions or suspensions of the components and spray drying them simultaneously in a spray drier. The hydrophobic component may be dissolved in an organic solvent and the hydrophilic component suspended therein. The method provides dry powders having relatively uniform characteristics.

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Sunnyvale, CA, United States of America

Marc S Gordon