Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Microparts Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Vectura Delivery Devices Limited

Marc Rohrschneider

Stephen Terence Dunne

Ralf Thoemmes

Timo Von Brunn

Jens Besseler

Holger Holakovsky

Florian Witte

Thomas Sowden Reinhold

Douglas Ivan Jennings

Achim Moser

Matthias Vehdelmann

Herbert Wachtel

Gert Blankenstein

Stephen William Eason

Charles William Sears

Matthew Neil Sarkar

Hubert Hoelz

Nicholas John Campling

Frank Herrmann

Graham Roger Gibbins

Kevin Peter Deane

Paul Bertram

Howard William Biddle

Joern-Eric Schulz

Rüdiger Belau

Campbell Patrick

Manuel Krakowka

Mario Alberto Gonzalez

Waldemar Masur

Tristian Roger Thornhill

Duncan James Bradley

Karl-Heinz Lange

Elvira Piel

Christopher Michael Catinella

Sean Landis Philips

Charles Henderson

Anke Klaer

Eric Jeske

A nebulizer is proposed as depicted in exemplary FIG.which comprises a replaceable container, a counting device and a lock for locking the nebulizer against further use. The container is provided with an electronic storage which is electrically connected to the counting device. The nebulizer comprises an electric drive for actuating the lock. This allows secure operation and/or simple handling of the nebulizer.

Nebulizer

The invention relates to pharmaceutical active substances, active substance mixtures and formulations for use as an aerosol in propellant-containing [1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)] metered-dose aerosols and the metered-dose aerosols for administering these active substances, active substance mixtures and formulations.

Dosage aerosols for the application of pharmaceutical formulations

A nebulizer is proposed which comprises a replaceable container containing fluid, a housing part detachable from the nebulizer for replacing the container, and an operation counter inseparable from the housing part as depicted in exemplary FIG.. The operation counter comprises a lead screw and an associated rider both supported by the housing part.

A spray head for an aerosol tank, and an aerosol tank having a spray head is provided, which includes a fluid exit valve for spraying a low-solvent fluid. The fluid exit valve of the aerosol tank defines an axial fluid exit direction. The spray head includes a capillary tube for routing the fluid and for nozzle-less spraying of the fluid. An entry end of the capillary tube is axially joined to the fluid exit valve when the spray head has been seated on the aerosol tank. An exit end of the capillary tube is open to the ambient atmosphere. In the spray head, the capillary tube runs from the entry end to the exit end in an arc of approximately 90&#xb0;.

Spray head for an aerosol tank

A dispensing device, a storage device and a method for dispensing powder in which powder is dispensed through a duct with a flat cross section to de-agglomerate the powder and to generate a spray with fine particle size. A storage chamber for the powder may be closed by a bursting element which is burst by pressurized gas for discharging the powder, the gas pressure reaching or exceeding a peak value before the bursting element bursts so that the powder is dispensed at a lower gas pressure. The powder may be forced through the duct by a gas pressure of less than 300 kPa to de-agglomerate the powder and/or to generate the spray. The storage device can have multiple storage chambers and associated ducts or nozzles, so that each dose of powder can be dispensed through a separate duct or nozzle.

Dispensing device, storage device and method for dispensing powder

A dispensing device, and a method for dispensing powder in which powder is dispensed through a duct with a flat cross section to de-agglomerate the powder and to generate a spray with fine particle size. A storage chamber for the powder may be closed by a bursting element which is burst by pressurized gas for discharging the powder, the gas pressure reaching or exceeding a peak value before the bursting element bursts so that the powder is dispensed at a lower gas pressure. The powder may be forced through the duct by a gas pressure of less than 300 kPa to de-agglomerate the powder and/or to generate the spray. The storage device can have multiple storage chambers and associated ducts or nozzles, so that each dose of powder can be dispensed through a separate duct or nozzle, the storage chamber and duct or nozzle being formed of a one-piece construction.

A nebulizer which has an insertable container and a counter device for counting operations of the nebulizer, and is opened for replacing the container. A securing device having locking portions which are forced apart is provided to prevent reconnection of an already used container. The nebulizer has an indicator for showing the current container number and/or symbols indicating the need container replacement. The indicator is driven by the force of an internal spring. The indicator member also controls a lock of the container for locking the container against further actuation. The lock is reset after container replacement.

A dispensing device has a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert by a connecting element that is moveable relative to the inserts for individually supplying air from a air pump to a respective one of the receptacles. A manually operated actuator is radially moveable to operate the air pump and to rotate the storage device to the next receptacle, and/or radially move the connecting element to individually open the respective receptacle, and to connect the pump to the respective receptacle and/or to push an insert out of the respective receptacle.

Dispensing device

A dispensing device, a storage device and a method for dispensing a medical formulation are proposed. Multiple doses of the formulation are stored in a carrier having multiple inserts, each insert containing a single dose. Preferably, each insert has at least one duct or nozzle for dispensing the respective dose. Each insert is located in a separate and sealed cavity in the carrier. The cavities can be individually opened for dispensing the respective dose from the respective insert.

Dispensing device, storage device and method for dispensing a formulation

A dispensing device has a storage device and an air pump for dispensing a medical formulation in which the storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert.

An atomizer, a reservoir and a method are proposed for the delivery and in particular, the atomization of a formulation, particularly a powder. A pump and a spring are arranged inside the annular reservoir, the pump and the spring being moveable radially and in a sliding manner. The pump is actuated by the spring to put air under pressure for discharging powder from the reservoir. The reservoir comprises receptacles or cavities, each of which has an insert with a respective dose of the formulation. The receptacles are constructed as separate parts and/or arranged on a common or annular carrier and/or are sealed separately and/or on its outer circumferential periphery. The spring is tensioned and the air is sucked into the pump. Then, the next receptacle and a connecting element are aligned relative to each other. Finally, the aligned receptacle is pierced by the connecting element for supplying the air.

Atomizer

A dispensing device with a storage device and an air pump for dispensing a medical formulation in which the storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert. Furthermore, a mechanism is provided for aligning the connecting element relative to a respective receptacle and/or insert which has guiding portions formed at or by the respective receptacle and/or insert.

A dispensing device having a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert by movement of the respective insert through the seal, so as to break the seal only at one side of the outlet opening so that the seal is pivoted mainly to an opposite side of the outlet opening by the movement of the insert for minimizing potential interference by the opened seal with flowing of the formulation from the receptacle toward the mouthpiece.

A dispensing device having a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert. At least one lifespan blocking device is provided for preventing operating of the dispensing device after a predetermined number of uses corresponding to the number of receptacles.

A dispensing device has a storage device and an air pump for dispensing a medical formulation. The storage device has multiple inserts, each insert containing a single dose of the formulation. Each insert is located in a separate and sealed cavity. The cavities can be individually opened for dispensing the respective dose from the respective insert by a pressurizing gas via a connecting element that is moveable relative to the inserts for individually supplying pressurized gas to a respective one of the receptacles. A mechanism is provided for preventing a back stroke of the connecting element during supplying of the pressurizing gas and dispensing of the formulation.

Growing community of inventors

Hagen, Germany

Marc Rohrschneider