Ciba-geigy Corporation

Novartis Ag

Novartis Finance Corporation

Novartis Corporation

Irm LLC

Novatis Ag

Marc Lang

Guido Bold

Hans-Georg Capraro

Alexander Fassler

Satish Chandra Khanna

Shripad S Bhagwat

Jaroslav Stanek

Edmond Differding

Pascal Furet

Peter Traxler

Peter Schneider

Alexander F&auml;ssler

Janis Karlis Lazdins

Jacques Gosteli

Vito Guagnano

Robert B Woodward

Ivan Ernest

J&ouml;rg Frei

Nathanael Schiander Gray

Yi Liu

Paul William Manley

Giorgio Caravatti

Andrea Vaupel

Werner Breitenstein

Tetsuo Uno

Qiang Ding

Guobao Zhang

Jorg Frei

Bing Li

Joseph Schoepfer

Taebo Sim

Carsten Spanka

Patricia Imbach

Carole Pissot Soldermann

Peter Van Hoogevest

Urs Regenass

Johannes Rosel

Frederic Cumin

The invention relates to compounds of formula (I) wherein the substituents X, R, R, Rand Rhave the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.

Compounds and compositions as protein kinase inhibitors

The invention relates to novel organic compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases. 

Heterobicyclic carboxamides as inhibitors for kinases

Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and the use of such derivatives in the preparation of pharmaceutical compositions for the therapeutic treatment of warm-blooded animals, including humans

2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives

Anilinopeptide derivatives

There are described compounds of formula I*,

Antivirally active heterocyclic azahexane derivatives

4-Amino-1H-pyrazolo&lsqb;3,4-d&rsqb;pyrimidine derivatives of formula I

Pyrimidine derivatives and processes for the preparation thereof

The invention relates to compounds of formula (I):

Azahexane derivatives as substrate isosters of retroviral asparate proteases

There are described 7H-pyrrolo&lsqb;2,3-d&rsqb;pyrimidine derivatives of the formula I

Substituted pyrrolopyrimidines and processes for their preparation

There are described compounds of formula I*, ##STR1## wherein R.sub.1 is lower alkoxycarbonyl,

Combinations of HIV protease inhibitors with reverse transcriptase

Pyrazole derivatives and processes for the preparation thereof

Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R.sub.1 is an acyl radical lower-alkoxy-lower-alkanoyl whose lower alkoxy radical is unsubstituted or is substituted by halogen, phenyl, lower alkoxy or a heterocyclic radical selected from piperidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolidinyl, thiazolyl, indolyl or 4H-1-benzopyranyl which is unsubstituted or substituted by oxo, hydroxyl, amino, lower alkyl, lower-alkoxycarbonyl and/or phenyl-lower-alkoxycarbonyl; lower alkanoyl which is unsubstituted or is substituted by one of the said unsubstituted or substituted heterocyclic radicals; arylcarbonyl or heterocyclylcarbonyl which are substituted by heterocyclyl or heterocyclyl-lower-alkyl; phenyl-lower-alkanoyl which is substituted by hydroxyl and lower alkyl; or arylsulfonyl;

Antiviral ethers of aspartate protease substrate isosteres

The invention relates to compounds of formula ##STR1## and salts, pharmaceutical compositions, intermediates and processes of preparation thereof.

Antiretroviral hydrazine derivatives

Growing community of inventors

Mulhouse, France

Marc Lang