Janssen Pharmaceutica Nv

Other

Marc Joris De Brabander

Jean Pierre Frans Van Wauwe

Nele Vandermaesen

Ludwig Paul Cooymans

Ludo Edmond Josephine Kennis

Christopher John Love

Gaston Stanislas Marcella Diels

Gerard Frans Cauwenbergh

Ludwig P Cooymans

Josepha Eduarda Leysen

Marc K Moeremans

Anne Simone Lesage

Petrus Franciscus Van De Plas

Mykhalyo Goncharenko

Johannes Leonardus Leunissen

Anthony William Sibley

Rony M Nuydens

Gustaaf M Geuens

Caterina Noula

Christopher Love

Roger Clive Moses

Gaston Stanislas Diels

Jean Pierre Van Wauwe

Mykhaylo Goncharenko

This invention concerns the use of a compound of formula (I')  

2,4-disubstituted thiazolyl derivatives

This invention concerns the use of a compound of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; Calkyl; Calkyl substituted with hydroxy, carboxyl, cyano, amino, mono- or di(Calkyl)amino, aminocarbonyl, mono- or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl or Calkyloxy; polyhaloCalkyl; Calkyloxy; cyano; amino; aminocarbonyl; mono- or di(Calkyl)aminocarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; HN&#x2014;S(&#x2550;O)&#x2014;; mono- or di(Calkyl)amino-S(&#x2550;O); &#x2014;C(&#x2550;N&#x2014;R)NRR; Q is an optionally substituted carbocycle or an optionally substituted heterocycle; L is substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through TNF-&#x3b1; and/or IL-12.

2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity

This invention concerns the use of a compound of formula (I') a N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form thereof, wherein Q is optionally substituted Ccycloalkyl, phenyl, naphthyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl; or Q is a radical of formula wherein X and Y each independently are O, NR, CHor S, with Rbeing hydrogen or Calkyl; q is 1 to 4; Z is O or NRwith Rbeing hydrogen or Calkyl; r is 1 to 3; L is optionally substituted phenyl or L is Het with Het being an optionally substituted five- or six-membered heterocyclic ring or an optionally substituted bicyclic heterocyclic ring; for the manufacture of a medicament for the prevention or the treatment of diseases mediated through cytokines.

Use of fused benzothiazoles as neuroprotectants

An aggregate for qualitatively or quantitatively determining bindable substances. Said aggregate comprises an ultra small colloidal particle and a specific binding agent characterized in that the mean diameter of the colloidal particle is below 2 nm. Preferably the size of the metal particle is selected so that the aggregate is capable of penetrating in standard biological specimens. The invention further provides a universally applicable detection system for determining bindable substances in particular in living material. Further there is provided a process for preparing said aggregate.

Universally applicable detection system based on ultra small colloidal

Agents for preserving or restoring the soundness of the skin by administering a serotonin antagonist which in particular is a compound of formula ##STR1## a salt or a stereoisomeric forms thereof; wherein Q is ##STR2## and R.sup.1 is --X--Ar (c), ##STR3## the agent of formula (I) preferably being ketanserin.

Agents for preserving or restoring the soundness of the skin

A method of visualizing individual submicroscopic metal particles by subjecting said particles to bright field or epi-polarization microscopy and enhancing the contrast of the image so obtained by electronic means.

Method of visualizing individual submicroscopic metal particles

Growing community of inventors

Zoersel, Belgium

Marc Joris De Brabander