Zeneca Limited

Imperial Chemical Industries Limited

Marc Jerome Chapdelaine

Charles D McLaren

Paul Francis Jackson

Laura Enid Garcia-Davenport

Jeffrey Alan McKinney

Timothy W Davenport

Gregory D Harris

William Jackson Frazee

Kelly Anne Brush

Joseph James Lewis

Paul F Jackson

Thomas Michael Bare

James Roy Empfield

Richard Bruce Sparks

The invention relates to azolobenzazepine derivatives of the formula I:

Azolobenzazepine derivatives and compositions and method of use thereof

The invention relates to pyridazinoquinoline compounds of the formulas B and B&prime;

Pyridazino quinoline compounds

Azolobenzazepine derivatives as neurologically active agents

Antagonists at the NMDA receptor complex which are benz�b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

Substituted nitrogen heterocycles

Benz�b!azepine compounds, pharmaceutical compositions containing them and methods for the treatment of neurological disorders utilizing them.

Therapeutic compositions

Antagonists at the NMDA receptor complex which are benz[b]azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

Benz[b]azepine compounds, pharmaceutical compositions containing them and methods for the treatment of neurological disorders utilizing them.

A method for the treatment of neurological disorders, comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I or of formula II (formulae set out on pages following the Examples), wherein

Therapeutic benzazapine compounds

Antagonists at the NMDA receptor complex which are benz b!azepines having a hydroxy, alkoxy or amino substituent at the 3-position and a 4-position alkenyl, alkynyl, aryl or heteroaryl substituent for treatment of stroke and/or other neurodegenerative disorders.

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Wilmington, DE, United States of America

Marc Jerome Chapdelaine