New York University

Tethis S.p.a.

Marc Henrik Baumann

Blas Frangione

Claudio Soto-Jara

Emanuele Barborini

Simone Vinati

There are described a new type of sample holder for performing analyses of biological samples with mass spectrometry in MALDI mode, the process for its production and some protocols for the use of the sample holder in said technique. The sample holder, in its simplest embodiment (), consists of a support () on a face () of which there is at least one porous deposit () consisting of nanoparticles of an oxide of a Group 4 metal.

Sample holder for mass spectrometry analysis in MALDI mode, production and use of the sample holder

Novel peptides capable of interacting with a hydrophobic &bgr;-sheet forming cluster of amino acid residues on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits and into pathological &bgr;-sheet-rich conformation as precursors thereof. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.

Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits

Novel peptides capable of interacting with a hydrophobic structural determinant on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.

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Helsinki, Finland

Marc Henrik Baumann