Bayer Cropscience S.a.

Bayer Cropscience Ag

Aventis Cropscience S.a.

Marc-Henri Lebrun

Marie-Claire Grosjean-Cournoyer

Marie-Pascale Latorse

Francois Villalba

Marie-Josee Daboussi

Géraldine Effantin

Valérie Morin

Renaud Dumas

Michel Droux

Jean-Luc Zundel

The invention relates to the use of methionine synthase inhibitors for the treatment of fungal diseases of crops. The invention further relates to methods for treatment of crops against fungal diseases comprising the application of a methionine synthase inhibitor also methods for the identification of novel fungicidal compounds comprising a step for identification of methionine synthase inhibitors.

Use of methionine synthase inhibitors for the treatment of fungal diseases of crops

The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic funguscomprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention also concerns the promoter of said gene, the gene coding for protein 763, protein 763 and uses thereof for identifying potential biological targets for novel fungicide molecules and for isolating genes coding for proteins controlling biochemical functions essential to the pathogenesis of the funguswith respect to rice and barley. The invention further concerns compounds inhibiting pathogenesis of fungi related to the expression of gene 763.

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The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterisedtransposon in the genome of said fungi. The invention also concerns the resulting mutants.

The invention concerns the use of ketol-acid reductoisomerase inhibitors for treating fungal diseases affecting crops. The invention concerns methods for treating crops against fungal diseases comprising applying a ketol-acid reductoisomerase inhibitor. The invention also concerns methods for identifying novel fungicidal compounds comprising a step which consists in identifying ketol-acid reductoisomerase inhibitors.

Use of ketol-acid reductoisomerase inhibitors to prevent or treat fungal infection of plants

The invention concerns a new tool for efficient mutagenesis enabling the generation of a collection of mutants in fungi by random insertion of a characterized Impala transposon in the genome of said fungi. The invention also concerns the resulting mutants.

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Lyons, France

Marc-Henri Lebrun