Dsm IP Assets B.v.

Marc Heidl

Eileen Jackson

Hugo Ziegler

Alexander Schlifke-Poschalko

Piero Geotti-Bianchini

Dominik Imfeld

Igor Bendik

Stéphanie Boudon

Martin Stöckli

Christian Ludin

Roman Wille

Thomas Schaerer

Florian David Glaus

The present invention relates to novel selective melanocortin-1 receptor (MC1R) agonists as well as the use thereof as skin tanning agents.

Melanocortin-1-receptor agonists

Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

Biaromatic compounds, which are vitamin D analogs

Biaromatic vitamin D analogs

The present invention relates to novel compounds which effectively inhibit the melanin synthesis in human melanocytes and are thus suitable for the treatment of senile lentigines, for smoothening skin color irregularities and/or for lightening natural skin color.

Compounds

The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11&#x3b2;-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

Selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors

(R)-N-(adamantyl-2-yl)pyrrolidine-2-carboxamide derivatives for cosmetic use

Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which Ris H, C-C-alkyl, cycloalkyl or aryl-C-C-alkyl, n is 1-4, X is &#x2014;O&#x2014;, &#x2014;NH&#x2014; or &#x2014;NR&#x2014; and RH or C-C-alkyl; and at least one compound corresponding to the above formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is &#x2014;NR&#x2014; and both Rand Rare different from H, and the compounds corresponding to formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid, as such.

Cosmetic composition for stimulating the synthesis of proteins of the basement membrane

The present invention relates to compositions comprising a peptide with 2-12 amino acids substituted with a lipophilic moiety and a water soluble salt of an alkali, earth alkaline metal or transition metal. Furthermore, the invention relates to a container comprising such compositions. Additionally, the invention relates to the use of a water soluble salt of an alkali, earth alkaline metal or transition metal for reducing the adhesion of a peptide with 2-12 amino acids substituted with a lipophilic moiety to a surface.

Composition

The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: Rrepresents H, &#x2014;C(O)&#x2014;R, &#x2014;SO&#x2014;Ror &#x2014;C(O)&#x2014;XR; Rand R, independent of one another, represent (CH)&#x2014;NHor (CH)&#x2014;NHC(NH)NH; n equals 1 4; Rrepresents linear or branched C-Calkyl that is optionally substituted by hydroxy; Rand R, independent of one another, represent hydrogen, optionally substituted (C-C)alkyl, optionally substituted C-Calkenyl, optionally substituted phenyl, optionally substituted phenyl-C-Calkyl or 9-fluorenyl-methyl; X represents oxygen (&#x2014;O&#x2014;) or NH&#x2014;; or XRwith X&#x2550;O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that Rand Rdo not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).

Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure

Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which Ris H, C-C-alkyl, cycloalkyl or aryl-C-C-alkyl, n is 1-4, X is &#x2014;O&#x2014;, &#x2014;NH&#x2014; or &#x2014;NR&#x2014; and RH or C-C-alkyl; and at least one compound corresponding to the above formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is &#x2014;NR&#x2014; and both Rand Rare different from H, and the compounds corresponding to formula (I) but in which XRwith X having the possible meaning of &#x2014;NH&#x2014; is the residue of an alpha-amino acid, as such. 

The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: Rrepresents H, &#x2014;C(O)&#x2014;R, &#x2014;SO&#x2014;Ror &#x2014;C(O)&#x2014;XR; Rand R, independent of one another, represent (CH)&#x2014;NHor (CH)&#x2014;NHC(NH)NH; n equals 1 4; Rrepresents linear or branched C-Calkyl that is optionally substituted by hydroxy; Rand R, independent of one another, represent hydrogen, optionally substituted (C-C) alkyl, optionally substituted C-Calkenyl, optionally substituted phenyl, optionally substituted phenyl-C-Calkyl or 9-fluorenyl-methyl; X represents oxygen (&#x2014;O&#x2014;) or &#x2014;NH&#x2014;; or XRwith X&#x2550;O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that Rand Rdo not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I). 

Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) wherein

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Kaiseraugst, Switzerland

Marc Heidl