Bristol-myers Squibb Compnay

Universitéde Montreal

Merck Frosst Canada, Inc.

Other

Merck Sharp + Dohme Corp.

Merck Frosst Canada & Co.

Merck Canada Inc.

Gagnon, Marc

Marc Gagnon

Edward H Ruediger

Shoshana L Posy

R Michael Lawrence

Daniel H Deon

Jacques Banville

Michael Matthew Miller

Pancras C Wong

Julia Guy

Eldon Scott Priestley

Brad D Maxwell

Richard W Friesen

Yves Ducharme

Richard Frenette

Roger Remillard

Laurence Dube

Erich L Grimm

Sebastien Laliberte

Yves Gareau

Bernard Cote

Andre Giroux

Helene Juteau

Evelyn Martins

Hongping Yu

Cheuk K Lau

Alain Martel

John Scheigetz

Marc Blouin

Jean-Francois Lavallee

Roger Rémillard

Laurence Dubé

Anh Chau

Tom Wu

Christophe Mellon

Michael Boyd

Dietmar A Seiffert

Michael R Lawrence

Francois Tremblay

Bruce MacKay

François Tremblay

Jean-François Lavallée

Bruce Mackay

Laurence DubÉ

Dietmar Alfred Seiffert

The present invention provides thiazole compounds of Formula I wherein W, Y, R, R, R, R, R, R, X, X, Xand Xare as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation

A system and method for storing, preserving and cooking meals using the sous-vide technique. The system and method of the present invention is designed to automatically cook, upon request a meal having various ingredients by immersing bagged food in temperature-controlled liquid. The cooking time may be manually or automatically programmed from downloaded cooking direction associated with the food. The cooking request may be given by a user from the physical apparatus or using a mobile device application.

Automated immersion apparatus and method for cooking meals

Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor4 (PAR4) inhibitors for treating platelet aggregation

A system and method for storing, preserving and cooking meals using the sous-vide technique. The system and method of the present invention is designed to automatically cook, upon request a meal having various ingredients by immersing bagged food in temperature controlled liquid. The cooking time may be manually or automatically programmed from downloaded cooking direction associated with the food. The cooking request may be given by a user from the physical apparatus or using a mobile device application.

The present invention provides thiazole compounds of Formula I wherein W, Y, R, R, R, R, R, R, X, X, Xand Xare as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders. 

The present invention provides benzothiazole compounds or benzothiophene compounds of Formula I having the structure: wherein X, X, X, X, X, Y, WR, R, R, R, R, Rand AA and other moieties are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders. 

Benzothiazole and benzothiophene compounds

The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, R, R, R, R, X, Xand s are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments. 

Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation

The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

Pharmaceutical phenylquinoline and chromen-2-one triazole compounds

The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

2-(phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors

The instant invention provides compounds of Formula Ia which are leukotriene biosynthesis inhibitors. Compounds of Formula Ia are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

Pharmaceutical compounds

This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. They have the following structure: Formula (I) 

Cathepsin cysteine protease inhibitors

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Montreal, Canada

Marc Gagnon