University of Toronto

Sunnybrook Research Institute

Marc G Jeschke

Axel Guenther

Navid Hakimi

Richard M Cheng

Richard Yihsiu Cheng

Gertraud Eylert

Sijin He

Jean-Michel Gariépy

Saeid Amini-Nik

Qing Ba

Mohammad Hadi Sotoudehfar

Richard Yi-Hsiu Cheng

Richard Cheng

Jean-Michel Gariepy

Disclosed herein is an instrument that enables the in situ formation of architected planar biomaterials and tissues by translating a printer head along a deposition surface such as a patient having burn injuries. In handheld embodiments of the instrument, cell-laden biopolymer solutions are perfused through a moving microfabricated printer head and deposited onto a stationary planar surface or a wound. The printer head may be translated via a drive mechanism. A soft deformable roller mitigates further damage to the injured area of skin as it rolls over it and a gimbal mechanism to which the printer head is attached is in contact with the injured tissue but is configured so that the printer head while in contact with tissue, does not exert undue pressure on the would area.

Devices and methods for wound-conformal guidance of bioprinter printhead

Disclosed herein is a bioprinter that enables the in situ formation of architected planar biomaterials and tissues by translating a printer head along a deposition surface, such as skin wounds. In handheld configurations of of the instrument, cell-laden biopolymer solutions are perfused through a moving microfabricated printhead and deposited onto a stationary planar surface or a wound. The printer head may be translated via a drive mechanism. Different embodiments of the instrument are disclosed form vivo application in small animals, as well as for large animal and clinical application. A stationary embodiment of the instrument is well suited for the continuous formation and roll-to-roll processing of planar biomaterials and tissues.

Tissue printer

Growing community of inventors

Toronto, Canada

Marc G Jeschke