Nestec S.a.

Centre National De La Recherche Scientifique

Ecole Normale Superieure De Lyon

Université Technologie De Compiègne-utc

Institut National De L'environment Industriel Et Des Risques

Institut National De L' Environnement Industriel Et Des Risques

Marc-Emmanuel Dumas

Serge Andre Dominique Rezzi

Francois-Pierre Martin

Sebastiano Collino

Sunil Kochhar

Jeremy Kirk Nicholson

Elaine Holmes

Claire L Boulange

Ivan Montoliu Roura

Eric Leclerc

Cécile Legallais

Régis Baudoin

François-Pierre Martin

Ivan Montoliu Rora

Laetitia Shintu

Pierre Toulhoat

Céline Brochot

Cecile Legallais

Regis Baudoin

Celine Brochot

Serge André Dominique Rezzi

The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be trimethylamine-N-oxide.

Trimethylamine-N-oxide as biomarker for the predisposition for weight gain and obesity

The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be isovalerylglycine.

Isovalerylglycine as biomarker for the predispositon for weight gain and obesity

The present invention relates to a method of toxicological evaluation of a candidate substance on at least one tissue or organ, characterized in that it comprises the steps of: (a) obtaining a bioartificial tissue or organ by simulation or modelling of the metabolic activity of said tissue or organ by at least one bioreactor; (b) exposure of said bioartificial tissue or organ to said substance; (c) observation of the metabolic response of the bioartificial tissue or organ and acquisition without a priori of an associated multidimensional data set; (d) identification by means of a method of multivariate statistical analysis of the components of the multidimensional data set which are quantitatively correlated with predetermined variables; (e) generation of a predictive model on the basis of the components of the data set that are actually retained; (f) testing of the predictive nature of said model by at least one statistical method of estimating reliability; (g) identification of the metabolic response of the bioartificial tissue or organ in the form of biomarkers associated with the components of the data set that are adopted for the model. The present invention also relates to a method of toxicological screening and to a system for this purpose.

Method of toxicological evaluation, method of toxicological screening and associated system

The present invention relates generally to the field of nutrition and health. In particular, the present invention relates to a new biomarker, its use and a method that allows it to diagnose the likelihood to resist diet induced weight gain, and/or to be susceptible to a diet induced weight gain. For example, the biomarker may be hexanoylglycine.

Hexanoylglycine as biomarker for the predisposition for weight gain and obesity

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Marc-Emmanuel Dumas