Sanofi-aventis

Marc Daumas

Philippe Vayron

Alain Dlubala

Raphael Sole

Raphaël Sole

A process for the preparation of for the preparation of N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide and of its salts, wherein 1,5-dibromopentane is reacted with a compound of formula (IIIa) in the presence of NaCOin acetonitrile heated at reflux.

Method for the preparation of N-piperidino-1, 5-diphenylpyrazole-3-carboxamide derivatives

The present invention comprises a process for the preparation of compounds that possess an affinity for the cannabinoid receptor in the human brain. These compounds are useful as immunomodulators and psychotropic agents in the treatment of thymic disorders, vomiting, myo-relaxation, various types of neuropathy, memory disorders, dyskinesia, migraine, asthma, epilepsy, glaucoma, anticancer chemotherapy, in ischemia and angina, in orthostatic hypotension and in cardiac distress. More specifically, the present invention comprises a process for the preparation of a series of compounds of formula (I): in which R-Rand W represent various alkyl groups and the derivatives thereof and are more specifically are defined herein.

Growing community of inventors

Oraison, France

Marc Daumas