Thomas Jefferson University

Rtm Vital Signs LLC

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Sri International

The Cooper Health System

Marc C Torjman

Jeffrey I Joseph

Nance K Dicciani

Denise L Devine

Channy Loeum

Noud Van Helmond

Irving William Wainer

Michel Bernier

Carlos A Zarate

Ruin Moaddel

Mary Jean Tanga

Michael E Goldberg

Jeffery I Joseph

David P Maguire

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

Acoustic sensor and ventilation monitoring system

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

Use of (2R, 6R)-hydroxynorketamine, (S)-dehydronorketamine and other stereoisomeric dehydro and hydroxylated metabolites of (R,S)-ketamine in the treatment of depression and neuropathic pain

The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment. 

The present invention relates to a drug delivery device which is implantable within a mammal and adapted for long-term efficient drug delivery to surrounding tissue. The drug delivery device is part of a drug delivery system that includes a catheter and a drug feed system. The drug delivery device includes a support structure that defines a drug reservoir and a capillary interface which facilitates vascular ingrowth while inhibiting blockage of drug delivery openings in the reservoir.

Implantable drug delivery catheter system with capillary interface

An anesthesia machine output monitor (AMOM) which performs the functions of measuring the flow and composition of anesthesia gases delivered by the anesthesia machine, measuring on-line the amount of inhaled anesthetic used during a procedure requiring an anesthetic agent, measuring on-line the cost of inhaled anesthetic used during a procedure requiring an anesthetic agent, and integrating with an automated anesthesia recorder (AAR) to allow the recording of anesthetic gas flow rates and composition during a procedure and the cumulative cost of the anesthetic gases used during the procedure. The anesthesia gas flow rates and composition are measured using a modified infrared anesthetic gas analyzer that measures anesthetic gas composition and a pitot tube that is inserted in the common gas outlet of the anesthesia machine in order to measure the composition and flow rates of gases as they exit the anesthesia machine. Anesthetic gas sampling is accomplished by aspirating anesthetic gases from a sampling port integrated into the pitot tube. The measured gas analog signals are then captured from an I/O port of the capnograph and provided to a processor for on-line processing. An automated anesthesia recorder is preferably provided to permit cost and compliance records to be maintained for each use of the anesthesia machine.

Anesthesia machine output monitor

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Southhampton, PA, United States of America

Marc C Torjman