The United States of America as Represented by the Department of Health

The United States of America as Represented by the Secretary of

Marc C Nicklaus

Victor E Marquez

Maqbool A Siddiqui

Juan B Rodriguez

Joseph J Barchi, Jr

Peter M Blumberg

Rajiv Sharma

Jeewoo Lee

Nancy E Lewin

George W Milne

Shaomeng Wang

Conformationally constrained diacylglycerol analogues, pharmaceutical compositions comprising such analogues, and methods of using such analogues as agonists and antagonists of protein kinase C.

Conformationally constrained diacylglycerol analogues

Conformationally locked 4',6'-cyclopropane-fused carboxylic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine, and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.

Conformationally locked nucleoside analogues

A method for treatment of herpes virus infection by administering an effective virus-inhibiting amount of a cyclopropanated carbocyclic 2'-deoxynucleoside to an individual in need thereof. The nucleoside analogs are effective against herpes simplex virus types 1 and 2; Epstein-Barr Virus and human cytomegalovirus.

Conformationally locked nucleoside analogs as antiherpetic agents

Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.

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Elkridge, MD, United States of America

Marc C Nicklaus