Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Societe De Conseils De Recherches Et D'applications Scientifiques

Societe D'expansion Scientifique Expansia

Marc Bonato

Michel Follet

Robert Jacquier

Charles Eck

Christian Aspisi

The present invention relates to stereospecific processes for the preparation of enantiomers of 3-substituted-furo[3,4-c]pyridine of formula I, wherein R.sub.3, R.sub.4 and R.sub.6 stand for various substituents, comprising the steps of: oxidation of a racemic pyridine derivative of formula II, reduction of the resulting ketone with a reducing agent, sterospecific locking or blocking of the OH group of the enantiomer alcohol, opening of the acetonide ring and cyclization of the resulting compound. ##STR1##

Stereospecific process for the preparation of furo[3,4-c]pyridine,

This invention relates to catechol derivatives having the general formula ##STR1## wherein R represents various substituents, to a process for the preparation of the same comprising reacting S-(3,4-dihydroxyphenyl)-isothiourea, which has the formula II, with a tosylate of the general formula III ##STR2## and to therapeutical compositions wherein the active ingredient is one of these compounds.

Catechol derivatives, a process of preparation thereof, and

This invention relates to bicyclic catechol derivatives having the general formulae I and II ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and Z represent various substituents, to a preparation process of the same comprising reacting a compound of formula III ##STR2## wherein R.sub.1 and R.sub.2 have the meanings given above with an appropriately substituted propionic or butyric acid (or an ester or a salt of the same) of formula IV ##STR3## wherein R.sub.3 has the meaning given above, and to therapeutical compositions wherein the active ingredient is one of these compounds.

Lipoxygenase and cyclogenase inhibiting thiachromen and thiepan

This invention relates to new chiral organoboranes of the general formula ##STR1## in which X represents a methylene group or a sulphur atom, n and p are 0 or 1, and to a preparation process of these compounds, consisting in reacting a bicyclic substituted di- or tri-thiane with a borane such as B.sub.2 H.sub.6 or BH.sub.3 : Lewis base.

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Aramon, France

Marc Bonato