Institut Pasteur

Centre National De La Recherche Scientifique

Other

Institut Pasteur and Centre National De La Recherche Scientifique

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Marc Alizon

Pierre Sonigo

Luc Montagnier

Simon Wain-Hobson

Mireille Guyader

Francois Clavel

Denise Guetard

Solange Chamaret

Oliver Danos

Cole Stewart

Jean-Claude Chermann

Christine Rouzioux

Denise Geutard

Pierre Tiollais

Christine Katlama

Marianne Rey

Francoise Brun-Vezinet

Stewart T Cole

Fran&ccedil;ois Clavel

Francoise Barre Sinoussi

Francedillaois Clavel

Fran&ccedil;oise Brun-Vezinet

Robert C Gallo

Francoise Barre-Sinoussi

Mangalasseril G Sarngadharan

Bernard Krust

Mikulas Popovic

Willy Rozenbaum

Francoise Rey

Claudine Axler-Blin

Charles Dauguet

Marie-Therese Nugeyre

Olivier Danos

François Clavel

Francois Brun-Vezinet

Jacques Gruest, Legal Representative

Denise Gu&eacute;tard

Wesley Loren Cosand

Raymond L Houghton

Andrew J Watson

Francedillaoise Barre-Sinoussi

Francedillaoise Brun-Vezinet

Denise Duetard

Françoise Brun-Vezinet

Fran&ccedil;oise Barre-Sinoussi

Luc Montangnier

Lisa Chakrabarti

Françoise Barre-Sinoussi

This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method to detect the presence of DNA, RNA, or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them, and the proteins expressed.

Nucleic acid probe of human immunodeficiency virus type 1 (HIV-1), and a method and kit employing this probe for detecting the presence of nucleic acid of HIV-1

This invention is in the field of lymphadenopathy virus. This invention relates to a diagnostic means and method of detecting lymphadenopathy associated virus or related viruses or DNA pro-viruses with cloned DNA sequences which are hybridizable to genomic RNA and DNA of lymphadenopathy associated virus. It further relates to the cloned DNA sequences and a process for their preparation.

Cloned DNA sequences hybridizable with genomic RNA of lymphadenopathy associated virus (LAV)

A variant of a LAV virus, designated LAVand capable of causing AIDS. The cDNA and antigens of the LAVvirus can be used for the diagnosis of AIDS and pre-AIDS.

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The inventors have isolated cloned cDNA encoding the RNA genome of Human Immunodeficiency Virus type 1 (HIV-1). Various clones are described, which encode different regions of the genome, including those regions encoding viral antigens or proteins. Hybridization results indicate the difference between the HIV-1 clones and those of HTLV-I and HTLV-II. The inventors have also produced a restriction map of the entire cloned genomic sequence in order to facilitate further subcloning and using the restriction fragments in other hybridization tests and in methods to express encoded sequences.

HIV-1 DNA fragments that hybridize to genomic HIV-1DNA

Method for detecting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity

This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus (HIV). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.

Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated-virus (LAV) and proteins encoded by said LAV genomic RNA

The invention relates to a composition comprising at least one antigen, wherein the antigen is a protein or glycoprotein of a HIV-2 virus, wherein the HIV-2 virus has infectious properties with respect to human T4 lymphocytes and the essential morphological or immunological property of at least one of the retroviruses deposited at the CNCM under No. I-502, I-532, I-642, and I-643. It also relates to a process for the production of HIV-2 retrovirus antigens by lysing cells infected with the virus or lysing purified virus and recovering the antigens.

HIV-2 antigen compositions

This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1) to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates tot he DNA fragments, vectors comprising them and the proteins expressed.

DNA sequence of the LTR region of human immunodeficiency virus type 1 (HIV-1)

This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.

Cloned DNA sequence related to genomic RNA of human immunodeficiency virus (HIV-1)

DNA sequences and peptides of human immunodeficiency virus (HIV-1)

The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399. It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis. It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hybridization probes, derived from the RNA of HIV-2.

Retrovirus capable of causing AIDS, means and methods for detecting it in vitro

Antibodies against antigens of human immunodeficiency virus (HIV-1)

Variant of LAV viruses

A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probes are capable of hybridizing to the entire genome of HIV-2. These reagents also include polypeptides encoded by some of these DNA sequences.

Human immunodeficiency virus type 2 (HIV-2) env polypeptide and diagnostic assays

Growing community of inventors

Paris, France

Marc Alizon