Genentech, Inc.

Constellation Pharmaceuticals, Inc.

Marc Adler

Steven R Magnuson

F Anthony Romero

Vickie Hsiao-Wei Tsui

Terry Crawford

Bing-Yan Zhu

Fei Wang

Christopher G Nasveschuk

Brian K Albrecht

Kevin X Chen

Martin Duplessis

Alexander M Taylor

Richard Pastor

Shumei Wang

Daniel J Burdick

Kwong Wah Lai

Alexandre Cote

Alexandre Côté

Steven Elliot Kauder

Sarah Bronner

Yong Tang

Jeremy M Murray

Patrick Cyr

Jiangpeng Liao

Jackson G Egen

Jackson Egen

The present invention relates to compounds of formula (I): and to salts thereof, wherein R-Rhave any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of TAF1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various TAF1-mediated disorders.

Therapeutic compounds and uses thereof

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R-Rof formula (I) and R-Rof formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Growing community of inventors

South San Francisco, CA, United States of America

Marc Adler