Bristol-myers Squibb Compnay

Marc A Bruce

Graham S Poindexter

Graham Johnson

Karen LeBoulluec

Sing-Yuen Sit

Charles P Sloan

Joseph P Yevich

Scott W Martin

Katherine S Takaki

Michael R Kozlowski

Yazhong Huang

Ivo Monkovic

Brett T Watson

R Thomas Swann

Leah M Giupponi

Ildiko Antal

Ramakrishna Seethala

Robert H Stoffel

James Guy Breitenbucher

Mendi A Morton

Jeffrey W Noonan

Alkylamine derivatives of dihydropyridine NPY antagonists

NPY antagonists: spiroisoquinolinone derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine NPY antagonists: cyanoguanidine derivatives

The present invention provides a series of non-peptidergic antagonists of NPY comprising piperidine derivatives of 4-phenyl-1,4-dihydropyrimidinones of the Formula I ##STR1## wherein R, R.sup.1 and R.sup.2 are defined herein. As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyrimidone derivatives as NPY antagonists

Novel substituted carbazole compounds of Formula I are active as melatonergic agents: ##STR1## wherein: R.sub.1 is C(O)R.sub.3 or SO.sub.2 R.sub.4 ;

Ethylamino carbazole melatonergic agents

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine NPY antagonists: piperidine derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine npy antagonists: piperazine derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives

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Wallingford, CT, United States of America

Marc A Bruce