Thornhill Scientific Inc.

Marat Slessarev

Joseph A Fisher

James Duffin

Michael Klein

Cathie Kessler

Olivia Sobczyk

David J Mikulis

Shoji Ito

Eitan Prisman

Daniel Michael Mandell

Joe Fisher

George Volgyesi

David Mikulus

Chris Hudson

Anne Battisti-Charbonney

Cliff Ansel

An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: &#x2014;obtaining input of a series of logistically attainable PetX values for a series of respective breaths: &#x2014;determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and&#x2014;controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

Method and apparatus to attain and maintain target arterial blood gas concentrations using ramp sequences

A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i]) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i]for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.

Apparatus to attain and maintain target end tidal partial pressure of a gas

In a first aspect, the invention relates to an apparatus for inducing or maintaining a target end tidal concentration of a gas in a subject comprising a breathing circuit, a source of gas flow into the circuit, means for controlling the rate of the source of gas flow into the circuit and means for controlling the concentration of gases in the source gas flow independently from each other. In another aspect, the invention relates to a method of preparing an apparatus for inducing or maintaining a target end tidal concentration of a gas X in a subject comprising selecting a rate of a source gas flow into a breathing circuit, selecting the concentration of at least one constituent gas of a component gas making up the source gas to a level corresponding to the end tidal concentration of the gas X, whereby the apparatus is adapted to administer a source gas having a first gas composition.

Method and apparatus to attain and maintain target end tidal gas concentrations

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Toronto, Canada

Marat Slessarev