Neuroderm, Ltd.

Aligena Ag

A. T. Ramot Plastics Ltd.

Membrane Products Kiryat Weitzman Ltd.

Other

Membrane Products Kiryat Weizmann Ltd.

Membrane Products Kiryat Weizman Ltd.

Membrane Products Kiryat Weisman, Ltd.

Mara Nemas

Charles Linder

Mordechai Perry

Oron Yacoby-Zeevi

Reuven Katraro

Reuven Ketraro

Menahem A Kraus

Moshe A Frommer

Rodika Gutman

Reuven Kotraro

Avinoam Livni

Eduardo Zawoznik

Henia Yacubowicz

The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly composition comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith.

Compositions comprising apomorphine and organic acids and uses thereof

Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.

Continuous administration of dopa decarboxylase inhibitors and compositions for same

Provided herein, in part, is a method of treating a neurological or movement disorder in a patient in need thereof, comprising subcutaneously administering to said patient a pharmaceutically acceptable composition comprising levodopa and optionally carbidopa and optionally entacapone or tolcapone, or pharmaceutically acceptable salts thereof, wherein said composition is administered substantially continuously, and compositions that can be used in the disclosed methods.

Continuous administration of L-dopa, dopa decarboxylase inhibitors, catechol-O-methyl transferase inhibitors and compositions for same

Disclosed herein are compositions that are useful in effecting the transdermal delivery of therapeutic agents. More particularly, the disclosed transdermal compositions may include a fatty alcohol (for example, octanol), a terpene (for example, limonene), and an active agent comprising an amine moiety.

Compositions for transdermal delivery of active agents

The present invention provides stable liquid or semi-solid pharmaceutical compositions of apomorphine, more particularly compositions comprising apomorphine and an organic acid, which are useful in treatment of neurological or movement diseases or disorders, e.g., Parkinson's disease, or conditions associated therewith.

The invention provides a process for producing a tubular membrane assembly comprising helically winding at least one strip of fibrous material on a mandrel to produce at least a single ply tubular support member for a semi-permeable membrane, characterized by passing the strip through a heated section of the mandrel during the helical winding thereof to flatten and smooth fibers protruding along the cross-sectional width of the strip, whereby a tube with a smooth inner bore along its entire length is formed.

Process for producing a tubular membrane assembly

The invention provides a multistage membrane system for the recovery of solvents and solutes from chromatographic systems, including first means for directing a first fluid stream of a main eluting fraction, containing target molecules to be concentrated and solvent, to a first filtration membrane unit for concentration and recovery of the target molecules at the feed side of the first membrane; second means for directing fluid streams of other eluting fractions of the chromatographic process, containing contaminants and solvent, to a second filtration membrane unit for concentration and collection of the contaminant solutes at the feed side of the second membrane unit; and third means for directing filtered solvent coming from the permeate side of the first filtration unit to the feed side of the second filtration membrane unit, whereby the filtered solvent intermixes with the fluid stream of other eluting fractions.

Growing community of inventors

Gedera, Israel

Mara Nemas