Vectorpharma International S.p.a.

Vectorpharma N.a. Inc.

Vectorpharma International Corporation

Mara L. Lovrecich

Mara L Lovrecich

Fabio Carli

Tiziana Canal

Giovanna Riccioni

Pharmaceutical compositions in the form of particles comprising a biodegradable polymer and/or a polysaccharide jellifying and/or bioadhesive polymer, an amphiphilic polymer, an agent modifying the interface properties of the particles and a pharmacologically active substance. Said compositions exhibit improved biocompatibility features and allow a controlled release of the active substance.

Pharmaceutical compositions in the form of particles suitable for the

A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a solvent able to swell the polymer. The product obtained by this treatment, and after being dried under vacuum, has a medicament dissolving rate which is considerably higher than that of the pure medicament.

Poorly soluble medicaments supported on polymer substances in a form

Supported drugs with an increased dissolution rate, prepared by a process comprising mixing the drug with the support material under dry conditions, co-grinding the mixture in a mill with its grinding chamber saturated with the vapour of one or more solvents able to solubilize the drug or to be adsorbed on the surface of the support material, vacuum-drying the product obtained, and sieving. The drugs obtained in this manner have a reduced heat of fusion, a reduced melting point, an increased dissolution rate and an increased solubilization kinetics.

Supported drugs with increased dissolution rate, and a process for their

Pharmaceutical tablets and capsule granulates for oral administration, with controlled release of the active substance, comprising scleroglucan and active substance and pharmaceutical acceptable excipients, said tablets being prepared by mechanically mixing said substances in the solid state and directly compressing, and said granulates being prepared by mechanically disintegrating said tablets.

Pharmaceutical tablets and capsule granulates of scleroglucan and active

Pharmaceutical tablets and capsule granulates for oral administration, with controlled release of the active substance, comprising scleroglucan and active substance and pharmaceutical acceptable excipients, said tablets being prepared by mechanically mixing said substances in the solid state and directly compressing, and said granulates being prepared by mechanically disgregating said tablets.

Pharmaceutical compositions including a microporous support and an active substance incorporated therein, the incorporation of the active substance being effected by adding the microporous support to a solution of the active substance, stirring the mixture obtained for at least 70 hours at ambient temperature and finally evaporating the solvent slowly.

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Trieste, Italy

Mara L Lovrecich