Fondazione Is. Insubrico Di Ricerca Per La Vita

Fondazione Istituto Insubrico Di Ricerca Per La Vita

Mara Brunati

Giacomo Carenzi

Gianpaolo Candiani

Linda Cavaletti

Lucia Carrano

Monica Abbondi

Anna Taravella

Alessandro Sigurta'

Paola Turconi

Giacomo Enrico Carenzi

The invention relates to a new family of proteolytic enxymes having the ability to hydrolize at a pH between 3 and 8 gluten olygopeptides which are resistant to cleavage by gastric and pancreatic enzymes and whose presence in the intestinal lumen results in toxic effects. The enzymes have been identified as endopeptidases of the S8/S53 family and are produced by anstrain. The object of the invention includes also methods for producing enzymes composition comprising the endopeptidases by cultivation of nativestrains, mutants thereof, or recombinant host cells comprising nucleic acids codifying for the endopeptidases. Said nucleic acids constitute a further object of the invention. The enzyme compositions comprising at least one endopeptidase of the invention are useful for the treatment and/or prevention of celiac sprue, dermatitis herpetiformis and any other disorder associated with gluten intolerance as ingredients of pharmaceutical formulations or as additives of foods and drinks.

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Olgiate Comasco, Italy

Mara Brunati