University of Southern California

Oregon Health & Science University

Maolong Tang

David E Huang

Yan Li

Ou Tan

Disclosed are systems and methods for characterizing corneal shape abnormalities. These methods may be used to differentiate corneas having subclinical keratoconus from other conditions which cause distortion of corneal shape, including warpage of the cornea due to contact lens wear. Also disclosed is classification scheme to aid diagnosis of corneal conditions and thereby guide clinical decision making regarding patient treatment. This classification scheme is based on computed properties of corneal shape, is amenable to automation, and may be implemented in an integrated system or provided in the form of software encoded on a computer-readable medium.

Diagnostic classification of corneal shape abnormalities

This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as well as parameters useful for evaluating the properties. The methods and systems described herein are useful as eye disease diagnostic tools and eye surgery planning tools.

Methods and systems to measure corneal epithelial thickness and power, stromal thickness, subepithelial corneal power and topography for disease diagnosis

The present invention discloses a method for characterizing ectatic diseases of the cornea by computing a mean curvature map of the anterior or posterior surfaces of the cornea and fitting the map to a Gaussian function to characterize the surface features of the map. Exemplary ectatic disease that may be characterized include keratoconus and pellucid marginal degeneration. Also disclosed are a system for diagnosing ectatic disease of the cornea and a computer readable medium encoding the method thereof.

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Portland, OR, United States of America

Maolong Tang