Zhejiang Hisun Pharmaceutical Co., Ltd.

Sinotherapeutics Inc.

Sinonutraceutical Co., Ltd.

Maojian Gu

Hua Bai

Min Wang

Ning Li

Xuyang Zhao

Jiansheng Wan

Xiaohe Zheng

Xiaoyu Liu

Qifeng Zhu

Xiaojie Xu

Yuncai Zhang

Kun Li

Yong Zhang

Hairong Luo

Chao Xu

Guixian Chen

Lan Zheng

Lintao Jiang

Ying Chen

Larry Yun Fang

Jianmei Su

Qilan Zheng

Disclosed in the present invention are a composition containing lutein/lutein ester and applications thereof. Components of the composition containing lutein/lutein ester comprise lutein/lutein ester, &#x3b2;-carotene and a pharmaceutically acceptable carrier. The weight ratio of lutein/lutein ester to &#x3b2;-carotene is 1:0.1-100. In the present invention, by cooperatively using lutein/lutein ester and &#x3b2;-carotene and using auxiliary natural healthy ingredients, the dosage form of an orally disintegrating tablet is prepared. The orally disintegrating tablet is absorbed through the oral cavity, has fast effectiveness and small first-pass effect, reduces damage of gastric acid to lutein/lutein ester, has high bioavailability, and has the characteristics of nutritional and health-care effects, good mouthfeel and fast absorption. By eating the product, visual power can be obviously enhanced, the ocular blood flow is increased, and eye muscle fatigue is alleviated, and accordingly the morbidities of cataract, senile niacula lutea retinae lesion and adolescent myopia are reduced.

Composition containing lutein/lutein ester and applications thereof

Disclosed are a ferroporphyrin solid dispersion, preparation method therefor and a pharmaceutical composition comprising the solid dispersion, wherein the weight ratio of ferroporphyrin to the carrier material in the dispersion is 1:1-1:10. The solid dispersion of the present invention masks the undesirable taste of ferroporphyrin, ameliorates irritation thereof to the digestive tract, and at the same time increases the solubility thereof and improves the bioavailability thereof.

Ferroporphyrin solid dispersion and preparation method thereof

Provided is an oral solid preparation of a compound anti-tubercular drug, wherein the active ingredients are rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride. The compound oral solid preparation is a coated tablet with coated core or a coated three-layer tablet, wherein the two active ingredients rifampicin and isoniazid do not come to contact with each other directly. The compound oral solid preparation not only improves the stability of the compound preparation, but also improves the bioavailability of rifampicin.

Oral solid formulation of compound anti-tubercular drug and preparation method thereof

Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R, R, R, R, Rand Rare defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention. 

Azetidinone compounds and medical use thereof

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Shanghai, China

Maojian Gu