Abmax Biotechnology Co., Ltd.

Shenzhen Wind Water Wheel New Energy Technology Co., Ltd.

Maohua Li

Le Sun

Hong Chen

Xiaogang Zhang

Cuijuan Zhang

Disclosed herein are low immunogenic human anti-TNF-&#x3b1;antibodies which can inhibit the apopotosis of cells induced by TNF-&#x3b1;. The invented low immunogenic human anti-TNF-&#x3b1; antibodies are capable of binding to TNF-&#x3b1; specifically. The invention presents the human anti-TNF-&#x3b1;antibodies which bind to TNF-&#x3b1; with similar affinities as Adalimumab. Most importantly, the invented human anti-TNF-&#x3b1; antibodies showed reduced immunogenicities in vivo, which made them safer candidate for antibody drug and other biotherapy. The invention also features method of de-immunogenicity of antibody drugs by identification, replacement of high immunogenic FR sequence(s) of the human antibody with low immunogenic FR sequences from other human IgGs, and significantly reduce the risk of human anti-human immunogenicity and improve the efficacy of antibody drugs.

Anti-TNF-&#x3b1; fully human monoclonal antibodies with low immunogenicity and application thereof

A wind generator with a water float sail includes a pond or a circular water tank containing liquid, a water float running system which can rotate in the pond or the circular water tank under the drive of wind and which includes a water float running platform floating on the liquid and several sails placed on the water float running platform, a location system which can locate the water float running system on the liquid surface, and make it rotate within a predetermined range, a brake system which can stop the rotation of the water float running system, and a generator system which can transform the energy produced by the water float running system into electric power output. The wind generator can make the water float running system floating on the liquid surface rotate, and it can generate electricity with low cost and high power.

Growing community of inventors

Beijing, China

Maohua Li