Atomic Energy Council-Institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Atomic Energy Council

Mao-Hsung Chang

Wuu-Jyh Lin

Jenn-Tzong Chen

Ting-Shien Duh

Sun-Rong Huang

Ying-Ming Tsai

Chien-Hsin Lu

Dow-Che Chen

Kuo-Yuan Chu

Chyng-Yann Shiue

Shiou-Shiow Farn

Li-Yuan Huang

Yean-Hung Tu

Ping-Yen Huang

Ying-Ming c/o Atomic En Council-Inst Of Nucl Energy Tsai

A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.

Compound of radiocontrast agent for tau protein

A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.

Circulated cooled target

A radioisotope TI-201 is produced. The process includes electroplating, irradiating, dissolving, precipitating, ion exchanging, decaying and filtering. The TI-201 obtained is a liquid having a high purity.

Radioisotope TI-201 production process

A device to rapidly obtain a solution of Pb(lead)-201 from a solution of a solid target material of Tl(thallium)-203. The solution of Pb-201 is then processed through a degeneration and an ion exchange to obtain in Tl-201 radioisotope.

Separation device of radioisotope Tl-201

Growing community of inventors

Hsinchu County, Taiwan

Mao-Hsung Chang